Gene expression profile of brain tissue from wildtype and GRN knock-out mice treated with an AAV driving expression of PTV-Progranulin in the liver
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degenerationScience translational medicine · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE260606_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1082327 and SRA study SRP492637. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 16 more — browse all 16 samples with per-sample file links →
- GSE273083 Transcriptomic profiling of mouse brain in PGRN KO, NesGrnOE-KOBG, EGFL7-PGRNdko and floxed control mice (Grnflfl) 28 samples shares grn, brain
- GSE291994 Combination of Cas9 and adeno-associated vectors (AAVs) enables efficient in vivo knockdown of precise miRNAs in the rodent brain 28 samples shares aav, brain
- GSE244970 RNA-seq analysis of the cerebellum of SCA7 mice treated with AAV expressing shRNA targeting Atxn7 20 samples shares aav, treated
- GSE206761 Transcriptome profile of thioacetamide treated mice injected with AAV8 TBG eGFP and AAV8 TBG miR34b/c 19 samples shares aav, treated
- GSE255987 Brain-wide AAV-mediated silencing of prion protein by a compact epigenetic editor 15 samples shares aav, brain
- GSE255812 ATACseq in muscle from mice treated with AAV-GFP or AAV-CAAHR 6 samples shares aav, treated
- GSE293041 Single-cell transcriptome analysis of wildtype, TREM2 knockout, GPR34 knock-out or TREM2/GPR34 double knock-out primary microglia from wildtype and APP knock-in mice (8 months) 10 samples shares knock-out, wildtype
- GSE293116 Single-cell transcriptome analysis of wildtype, TREM2 knockout, GPR34 knock-out or TREM2/GPR34 double knock-out primary microglia from wildtype and APP knock-in mice (17 months) 8 samples shares knock-out, wildtype
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.