RNA-seq analysis of the cerebellum of SCA7 mice treated with AAV expressing shRNA targeting Atxn7
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- AAV-Mediated CAG-Targeting Selectively Reduces Polyglutamine-Expanded Protein and Attenuates Disease Phenotypes in a Spinocerebellar Ataxia Mouse ModelInternational journal of molecular sciences · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244970_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1026540 and SRA study SRP465457. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 20 more — browse all 20 samples with per-sample file links →
- GSE206761 Transcriptome profile of thioacetamide treated mice injected with AAV8 TBG eGFP and AAV8 TBG miR34b/c 19 samples shares aav, treated
- GSE244342 Activated-ATF6α is an ER stress-inducing oncoprotein metabolically restricting immunosurveillance [bulk RNA-seq of TG-AAV-GFP/CRE, DEN/HFD] 16 samples shares aav, rna-seq
- GSE260606 Gene expression profile of brain tissue from wildtype and GRN knock-out mice treated with an AAV driving expression of PTV-Progranulin in the liver 16 samples shares aav, treated
- GSE327575 TET2_x001E_mediated PTPN6 demethylation drives post_x001E_burn immune paralysis and AAV_x001E_CRISPRi targeting PTPN6 improves secondary bloodstream infection outcome 12 samples shares aav, targeting
- GSE278331 Effect of an AAV1 containing an sh-RNA targeting Angptl2 on the hypocampus of male and female atherosclerotic mice 12 samples shares aav, targeting
- GSE246524 In Vivo Direct Reprogramming by AAV Improves Cardiac Function after Myocardial Infarction. [RNA-seq] 10 samples shares aav, rna-seq
- GSE316845 RNA-Seq Results of Hearts from Mice in the Sham Group, Sepsis-Induced Cardiomyopathy Group, and AAV-GATA4 Group 9 samples shares aav, rna-seq
- GSE312357 Multi-omics Analysis of Immune Cells Induced by Artificial Adjuvant Vector Cell (aAVC) Therapy in HPV-Positive Tumor-Bearing Mice [scRNA-seq] 8 samples shares aav, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.