← BioTransfer GEO Dataset Finder
GEO series

Translational regulation of chaperone-mediated autophagy by the RNA-binding protein IMP2

GSE260682 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/15 Platform GPL21103
Summary
Chaperone-mediated autophagy (CMA) selectively targets proteins for lysosomal degradation. During aging, levels of LAMP2A (lysosome-associated membrane protein 2A), a limiting CMA component, decline. Here we show that insulin-like growth factor 2 mRNA-binding protein 2 (IMP2), is a post-transcriptional regulator of CMA that binds Lamp2a mRNA and inhibits its translation, leading to decreased CMA activity and that IMP2 depletion or pharmacological inhibition effectively upregulate CMA. We identified a fraction of IMP2 at the lysosomal surface and using single-molecule fluorescence in situ hybridization, demonstrated its contribution to the lysosomal degradation of Lamp2a mRNA. IMP2 levels and distribution change with age and in response to dietary lipid challenges, both conditions known to reduce CMA activity. We propose that the increase in IMP2 levels under these conditions enhances Lamp2a RNA degradation, thereby contributing to the decline of CMA. Our data highlight IMP2 as a physiological regulator of CMA activity and potential target for gerotherapeutic interventions.
Published in
HyperTRIBE identifies hepatic IGF2BP2/IMP2 targets in vivo and links IMP2 to autophagy
Do HTT, Both S, Kröhler T et al. · NAR molecular medicine 2026 · PMID 42441288 · doi:10.1093/narmme/ugag034
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE260682_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1082693 and SRA study SRP492823. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.