Transcriptomics profiling of white adipose tissue of wildtype (WT) and miR-10a knockout (KO) mice fed a normal chow diet (NCD) or high-fat diet (HFD)
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × gWAT WT NCD vs 3 × gWAT KO NCD vs 3 × gWAT WT HFD vs 3 × gWAT KO HFDGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- miR-10a regulates cell death and inflammation in adipose tissue of male mice with diet-induced obesityMolecular metabolism · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE260771_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1083460 and SRA study SRP493149. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8124223 gWAT WT NCD_rep1 gWAT WT NCD
- GSM8124224 gWAT WT NCD_rep2 gWAT WT NCD
- GSM8124225 gWAT WT NCD_rep3 gWAT WT NCD
- GSM8124226 gWAT KO NCD_rep1 gWAT KO NCD
- GSM8124227 gWAT KO NCD_rep2 gWAT KO NCD
- GSM8124228 gWAT KO NCD_rep3 gWAT KO NCD
- GSM8124229 gWAT WT HFD_rep1 gWAT WT HFD
- GSM8124230 gWAT WT HFD_rep2 gWAT WT HFD
- GSM8124231 gWAT WT HFD_rep3 gWAT WT HFD
- GSM8124232 gWAT KO HFD_rep1 gWAT KO HFD
- GSM8124233 gWAT KO HFD_rep2 gWAT KO HFD
- GSM8124234 gWAT KO HFD_rep3 gWAT KO HFD
- GSE280875 Transcriptomics profiling of gonadal white adipose tissue (gWAT) of wild-type (WT) and macrophage-specific Bnip3 knockout (MKO) mice fed a normal chow diet (NCD) or high-fat diet (HFD) 12 samples shares ncd, hfd, knockout, high-fat, adipose, normal
- GSE288211 Single-cell gene expression profiles of pancreatic islets from two β-cell specific knockout mouse models (βZKO-Mip and βZKO-Rip), along with RIP-Cre and MIP-Cre mice, were analyzed after being fed a high-fat diet (HFD). 8 samples shares hfd, knockout, high-fat
- GSE273688 Gene expression profile at single cell level of islets from two β-cell specific knockout mouse models (βZKO-Mip and βZKO-Rip), littermate controls (Zzef1f/f), and the MIP-Cre mice fed with normal-chow diet (NCD). 8 samples shares ncd, knockout, normal
- GSE223143 Gene expression data of islets from Zzef1 global knockout (Zzef1_KO) mice and littermate controls (WT) mice fed with normal-chow diet (NCD) [bulk RNA-seq] 7 samples shares ncd, knockout, normal
- GSE310493 Single-cell analysis results of pituitary tissue from normal diet (ND) mice and high-fat diet (HFD) mice 4 samples shares hfd, high-fat, normal
- GSE336234 scRNA-seq analysis of peritoneal immune cells from NCD- and HFD-fed mice 4 samples shares ncd, hfd
- GSE232928 Transcriptional profiling of mature murine adipocytes of the inguinal white adipose tissue depot following LPCAT3 deletion and HFD-induced adipose hypertrophy. 24 samples shares hfd, adipose
- GSE294416 Regulation of Redox Homeostasis by ATF4-MTHFD2 Axis during White Adipose Tissue Browning 12 samples shares hfd, adipose
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.