Transcriptomics profiling of gonadal white adipose tissue (gWAT) of wild-type (WT) and macrophage-specific Bnip3 knockout (MKO) mice fed a normal chow diet (NCD) or high-fat diet (HFD)
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × gWAT WT NCD vs 3 × gWAT MKO NCD vs 3 × gWAT WT HFD vs 3 × gWAT MKO HFDGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- BNIP3-mediated mitophagy in macrophages regulates obesity-induced adipose tissue metaflammationAutophagy · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280875_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1180959 and SRA study SRP543117. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8606824 gWAT WT NCD_rep1 gWAT WT NCD
- GSM8606825 gWAT WT NCD_rep2 gWAT WT NCD
- GSM8606826 gWAT WT NCD_rep3 gWAT WT NCD
- GSM8606827 gWAT MKO NCD_rep1 gWAT MKO NCD
- GSM8606828 gWAT MKO NCD_rep2 gWAT MKO NCD
- GSM8606829 gWAT MKO NCD_rep3 gWAT MKO NCD
- GSM8606830 gWAT WT HFD_rep1 gWAT WT HFD
- GSM8606831 gWAT WT HFD_rep2 gWAT WT HFD
- GSM8606832 gWAT WT HFD_rep3 gWAT WT HFD
- GSM8606833 gWAT MKO HFD_rep1 gWAT MKO HFD
- GSM8606834 gWAT MKO HFD_rep2 gWAT MKO HFD
- GSM8606835 gWAT MKO HFD_rep3 gWAT MKO HFD
- GSE260771 Transcriptomics profiling of white adipose tissue of wildtype (WT) and miR-10a knockout (KO) mice fed a normal chow diet (NCD) or high-fat diet (HFD) 12 samples shares ncd, hfd, knockout, high-fat
- GSE288211 Single-cell gene expression profiles of pancreatic islets from two β-cell specific knockout mouse models (βZKO-Mip and βZKO-Rip), along with RIP-Cre and MIP-Cre mice, were analyzed after being fed a high-fat diet (HFD). 8 samples shares hfd, knockout, high-fat
- GSE336234 scRNA-seq analysis of peritoneal immune cells from NCD- and HFD-fed mice 4 samples shares ncd, hfd
- GSE285265 Liver transcriptomic profile of wild type and hepatocyte-specific ATF6 knockout mice feeding CD-HFD 11 samples shares hfd, knockout
- GSE217560 Gene expression profile at single cell level of bone marrow and brain cells from young adult and aged mouse after chewing diet (CD) and long-term high-fat diet (HFD) feeding 8 samples shares hfd, high-fat
- GSE273688 Gene expression profile at single cell level of islets from two β-cell specific knockout mouse models (βZKO-Mip and βZKO-Rip), littermate controls (Zzef1f/f), and the MIP-Cre mice fed with normal-chow diet (NCD). 8 samples shares ncd, knockout
- GSE223143 Gene expression data of islets from Zzef1 global knockout (Zzef1_KO) mice and littermate controls (WT) mice fed with normal-chow diet (NCD) [bulk RNA-seq] 7 samples shares ncd, knockout
- GSE310493 Single-cell analysis results of pituitary tissue from normal diet (ND) mice and high-fat diet (HFD) mice 4 samples shares hfd, high-fat
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.