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Single-cell gene expression profiles of pancreatic islets from two β-cell specific knockout mouse models (βZKO-Mip and βZKO-Rip), along with RIP-Cre and MIP-Cre mice, were analyzed after being fed a high-fat diet (HFD).

GSE288211 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/09/22 Platform GPL28330
Summary
The islet is composed of diverse cell types that work together to regulate its endocrine function. To investigate this, we performed comparative single-cell RNA sequencing (scRNA-seq) on islets from 16-week-old βZKO-Mip, βZKO-Rip, RIP-Cre, and MIP-Cre mice, all of which were fed a high-fat diet (HFD) from 12 to 16 weeks. Sequencing was carried out using the Chromium Next GEM Single Cell 3' Reagent Kits. Each islet sample was derived from at least three mice with the same genotype.
Published in
Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes
Nan J, He X, Liu X et al. · Nature metabolism 2026 · PMID 41482566 · doi:10.1038/s42255-025-01407-6
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Direct links to NCBI, no account and no request form: the whole study as GSE288211_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1216580 and SRA study SRP560454. Searching any of these in the dataset finder brings you back here.

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