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New therapy for colorectal cancer targeting cancer metabolism through serotonin receptor HTR2B

GSE260979 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/12 Platform GPL21697
Summary
Serotonin is important material in our body. 5-HT is synthesized by TPH1 starting with tryptophan and this compound exists on colorectal cancer. And serotonin combines with various receptors to conduct the metabolic pathway in colorectal cancer. Each receptor relates with various metabolism, such as lipid metabolism, growth, immunity, etc. In this way, medicine which inhibits these receptors can expect for therapy of colorectal cancer. Especially HTR 2B has correlation with growth factor and using the inhibitor of HTR2B, SB204741, can have effect on metabolic pathway in colorectal cancer. So, we set the hypothesis that HTR2B antagonist can have negative effect on growth of colorectal cancer.
Published in
Inhibition of HTR2B-mediated serotonin signaling in colorectal cancer suppresses tumor growth through ERK signaling
Lee JY, Park S, Park EJ et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 · PMID 39255737 · doi:10.1016/j.biopha.2024.117428
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Also filed as BioProject PRJNA1084766 and SRA study SRP493645. Searching any of these in the dataset finder brings you back here.

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