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transcriptional responses of LPS-stimulated microglia in Alzheimer's disease

GSE261007 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/11 Platform GPL24247
Summary
Neuroimmunity is present as an important mechanism in the brains of Alzheimer's patients, and microglia are a key component of the brain's innate immune response during the development and progression of Alzheimer's disease. The interferon pathway plays an important role in the pathophysiologic mechanisms of AD. RNA-seq was performed on LPS-treated microglia(LPS) and untreated microglia(WT) to further explore.
Published in
Critical role of Oas1g and STAT1 pathways in neuroinflammation: insights for Alzheimer's disease therapeutics
Xie Z, Li L, Hou W et al. · Journal of translational medicine 2025 · PMID 39953505 · doi:10.1186/s12967-025-06112-2
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Also filed as BioProject PRJNA1084816 and SRA study SRP493680. Searching any of these in the dataset finder brings you back here.

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