Gene expression of TPO-stimulated HSC-derived murine Evi1+AML
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Thrombopoietin increases susceptibility for EVI1 + KMT2A-MLLT3-driven AML expressing stem cell genes linked to poor outcomeNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261134_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1085341 and SRA study SRP494018. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 6 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8135585 BM cells, noTPO, bulk, rep1 BM cells, noTPO, bulk,
- GSM8135586 BM cells, noTPO, GFP-, rep2 BM cells, noTPO, GFP-,
- GSM8135587 BM cells, TPO, GFP+, rep3 BM cells, TPO, GFP+,
- GSM8135588 BM cells, TPO, bulk, rep3 BM cells, TPO, bulk,
- GSM8135589 BM cells, TPO, GFP-, rep4 BM cells, TPO, GFP-,
- GSM8135590 BM cells, TPO, GFP+, rep4 BM cells, TPO, GFP+,
- GSM8135591 BM cells, noTPO, GFP-, rep1 BM cells, noTPO, GFP-,
- GSM8135592 BM cells, noTPO, GFP+, rep5 BM cells, noTPO, GFP+,
- GSM8135593 BM cells, noTPO, GFP+, rep2 BM cells, noTPO, GFP+,
- GSM8135594 BM cells, noTPO, GFP-, rep5 BM cells, noTPO, GFP-,
- GSM8135595 BM cells, TPO, bulk, rep6 BM cells, TPO, bulk,
- GSM8135596 BM cells, noTPO, GFP-, rep7 BM cells, noTPO, GFP-,
- GSM8135597 BM cells, TPO, GFP-, rep3 BM cells, TPO, GFP-,
- GSM8135598 BM cells, noTPO, GFP+, rep7 BM cells, noTPO, GFP+,
- GSM8135599 BM cells, TPO, GFP+, rep8 BM cells, TPO, GFP+,
- GSM8135600 BM cells, TPO, GFP+, rep6 BM cells, TPO, GFP+,
- GSM8135601 BM cells, noTPO, GFP+, rep1 BM cells, noTPO, GFP+,
- GSM8135602 BM cells, TPO, bulk, rep4 BM cells, TPO, bulk,
- GSM8135603 BM cells, noTPO, bulk, rep5 BM cells, noTPO, bulk,
- GSM8135604 BM cells, noTPO, bulk, rep7 BM cells, noTPO, bulk,
- GSM8135605 BM cells, TPO, GFP-, rep8 BM cells, TPO, GFP-,
- GSM8135606 BM cells, TPO, bulk, rep8 BM cells, TPO, bulk,
- GSM8135607 BM cells, noTPO, bulk, rep2 BM cells, noTPO, bulk,
- GSM8135608 BM cells, TPO, GFP-, rep6 BM cells, TPO, GFP-,
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.