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Inflammatory milieu by crosstalk between podocytes and proximal tubular cells in type 2 diabetic kidney disease

GSE261356 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/01 Platform GPL24247
Summary
Due to the limited availability of therapeutic agents for type 2 diabetic kidney disease (DKD), there is a need for further knowledge derived from experimental models and innovative techniques. In addressing this issue, single-cell RNA sequencing (scRNA-seq) has been exclusively applied to a genetically modified DKD model, but not an induced model representing type 2 DKD. Herein, we analyzed scRNA-seq and other experiments from an induced type 2 DKD model, and validated the results in human-derived biospecimens. The model was induced by combining a high-fat diet with streptozotocin to simulate induced type 2 DKD. scRNA-seq, histological, and flow cytometric analyses were conducted, and their results were compared with control mice. The findings were then applied to human kidneys exhibiting diabetic glomerulosclerosis associated with type 2 diabetes.
Published in
Inflammatory Milieu by Crosstalk between Glomerulus and Proximal Tubular Cells in Type 2 Diabetes Mellitus Kidney Disease
Park PG, Hwang J, Kim Y et al. · Diabetes & metabolism journal 2025 · PMID 40160027 · doi:10.4093/dmj.2024.0535
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Also filed as BioProject PRJNA1086552 and SRA study SRP494623. Searching any of these in the dataset finder brings you back here.

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