Transcriptomic signature and pro-osteoclastic secreted factors of abnormal bone marrow stromal cells in fibrous dysplasia
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 6 × Healthy dono vs 6 × Fibrous dysplasiaGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptomic Signature and Pro-Osteoclastic Secreted Factors of Abnormal Bone-Marrow Stromal Cells in Fibrous DysplasiaCells · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261360_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1086550 and SRA study SRP494619. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 4 samples read as cases, 10 as controls.
How we read this: 2 replicated groups read from 20 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8141359 Healthy donor_1 Healthy dono
- GSM8141360 Healthy donor_2 Healthy dono
- GSM8141361 Healthy donor_3 Healthy dono
- GSM8141362 Healthy donor_4 Healthy dono
- GSM8141363 Healthy donor_5 Healthy dono
- GSM8141364 Healthy donor_6 Healthy dono
- GSM8141365 Fibrous dysplasia_1 Fibrous dysplasia
- GSM8141366 Fibrous dysplasia_2 Fibrous dysplasia
- GSM8141367 Fibrous dysplasia_3 Fibrous dysplasia
- GSM8141368 Fibrous dysplasia_4 Fibrous dysplasia
- GSM8141369 Fibrous dysplasia_5 Fibrous dysplasia
- GSM8141370 Fibrous dysplasia_6 Fibrous dysplasia
- GSM8141371 F1293_female_control
- GSM8141372 F1162_male_control
- GSM8141373 F1290_male_control
- GSM8141374 F1342_male_control
- GSM8141375 F1293_female_induced
- GSM8141376 F1162_male_induced
- GSM8141377 F1290_male_induced
- GSM8141378 F1342_male_induced
- GSE223550 Secretion encoded single-cell sequencing (SEC-seq) uncovers gene expression signatures associated with high VEGF-A secretion in mesenchymal stromal cells 13 samples shares signature, stromal
- GSE271871 A leiomodin 2 neonatal dilated cardiomyopathy causing mutation results inaltered actin-regulatory gene signatures andcardiomyocyte dysfunction 42 samples shares signature
- GSE288077 Metabolic dysfunction-associated steatotic liver disease may increase intrahepatic interferon gene signatures in patients with chronic hepatitis B 35 samples shares signature
- GSE152277 G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT 30 samples shares secreted
- GSE315101 Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs oligodendrocyte functions and alters neuronal activity [DLK1_snRNA-seq] 27 samples shares secreted
- GSE262137 Perfluorooctanesulfonic acid alters pro-cancer phenotypes and metabolic and transcriptional signatures in testicula germ cell tumors 26 samples shares signature
- GSE97179 Single Cell Methylome Signatures Reveal Distinct Neuronal Populations and Regulatory Elements in the Mammalian Cortex 6172 samples shares signature
- GSE281902 Periosteum Signatures of Delayed Fracture Healing in Type 2 Diabetes at Single-Cell Resolution 5 samples shares signature
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.