Glomerular Haematopoietic Prostaglandin D Synthase‐Prostaglandin D2 Axis Contributes to the Periodontitis‐Related Exacerbation of Diabetic Nephropathy in KK‐Ay Mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Glomerular Haematopoietic Prostaglandin D Synthase-Prostaglandin D2 Axis Contributes to the Periodontitis-Related Exacerbation of Diabetic Nephropathy in KK-A(y) MiceJournal of clinical periodontology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261386_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1086826 and SRA study SRP494719. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8141816 C57BL/6 mouse without ligature 1 [C1]
- GSM8141817 C57BL/6 mouse without ligature 2 [C2]
- GSM8141818 C57BL/6 mouse without ligature 3 [C3]
- GSM8141819 C57BL/6 mouse with ligature for 3 weeks 1 [CL1]
- GSM8141820 C57BL/6 mouse with ligature for 3 weeks 2 [CL2]
- GSM8141821 C57BL/6 mouse with ligature for 3 weeks 3 [CL3]
- GSM8141822 KK-Ay mouse without ligature 1 [K1]
- GSM8141823 KK-Ay mouse without ligature 2 [K2]
- GSM8141824 KK-Ay mouse without ligature 3 [K3]
- GSM8141825 KK-Ay mouse with ligature for 3 weeks 1 [KL1]
- GSM8141826 KK-Ay mouse with ligature for 3 weeks 2 [KL2]
- GSM8141827 KK-Ay mouse with ligature for 3 weeks 3 [KL3]
- GSE308485 Prostaglandin D2 Synthase: A novel Player in the Pathological Signaling Mechanism of the Aldosterone–Mineralocorticoid Receptor Pathway in the Heart 6 samples shares prostaglandin, synthase
- GSE223366 Maintenance of ESLAM haematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition 288 samples shares haematopoietic
- GSE315842 Cytomegalovirus as a risk factor for exacerbation of Mycobacterium tuberculosis: development of a Mtb-CMV mouse model infection 54 samples shares exacerbation
- GSE328134 Adipose tissue inflammation mediated by CCL19 overexpression exacerbates experimental periodontitis via elevated circulating saturated fatty acids and osteopontin in Western-diet-fed mice 36 samples shares periodontitis
- GSE292710 Traumatic occlusion exacerbates bone resorption by modifying gene expression in the bone tissue of ligature-induced periodontitis in mice 32 samples shares periodontitis
- GSE318701 Lung fibroblasts contribute to release of Serum Amyloid A as potential biomarker of exacerbation of lung fibrosis in mice [RNA-seq] 32 samples shares exacerbation
- GSE245259 The soluble factor milieu in IPF and in COPD exacerbations dysregulates epithelial differentiation 30 samples shares exacerbation
- GSE327719 Estrogen deprivation alters gingival and dentoalveolar complex transcriptomes during ligature-induced periodontitis in mice 24 samples shares periodontitis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.