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Single-cell transcriptional analysis of kidney from aging mice with podocyte specific RARRES1 overexpression

GSE261402 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/06/26 Platform GPL24247
Summary
Retinoic acid receptor responder protein-1 (RARRES1) was identified as a podocyte transmembrane protein whose expression correlates with glomerular disease progression. The cytopathic effect of RARRES1 is carried out only when proteolytically cleaved in its ectodomain into a soluble form (sRARRES1) and subsequently endocytosed by podocytes, as a membrane-bound, cleavage site mutant failed to induce any effect. We investigated the effects of long-term podocyte-derived RARRES1 overexpression on aging-induced kidney injury.
Published in
Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury
Feng Y, Sun Z, Fu J et al. · Kidney international 2024 · PMID 38697478 · doi:10.1016/j.kint.2024.04.011
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Also filed as BioProject PRJNA1086874 and SRA study SRP494849. Searching any of these in the dataset finder brings you back here.

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