GEO series
Hippocampal DNA methylation promote memory persistence by facilitating systems consolidation and cortical engram stabilization
GSE261404
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2025/03/10
GPL23479
Summary
The long-term stabilization of memory traces or engram involves the rapid formation of cortical engrams during encoding that mature functionally over time guided by the activity of the hippocampus. The molecular mechanisms that regulate this process remain largely unknown. Here, we found that hippocampal DNA methylation converts short-lasting into long-lasting memories by promoting systems consolidation and the stabilization of cortical engrams.
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Paper (PMID 39880069) ↗
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