Hippocampal DNA methylation promote memory persistence by facilitating systems consolidation and cortical engram stabilization
DNA methylation · mouse · 16 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × Dnmt3a2_1d vs 4 × Dnmt3a2_5d vs 4 × Control_1d vs 4 × Control_5dGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hippocampal DNA Methylation Promotes Contextual Fear Memory Persistence by Facilitating Systems Consolidation and Cortical Engram StabilizationBiological psychiatry · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261404_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1086880 and SRA study SRP494831. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8142298 Dnmt3a2_1d_Rep1 Dnmt3a2_1d
- GSM8142299 Dnmt3a2_1d_Rep2 Dnmt3a2_1d
- GSM8142300 Dnmt3a2_1d_Rep3 Dnmt3a2_1d
- GSM8142301 Dnmt3a2_1d_Rep4 Dnmt3a2_1d
- GSM8142302 Dnmt3a2_5d_Rep1 Dnmt3a2_5d
- GSM8142303 Dnmt3a2_5d_Rep2 Dnmt3a2_5d
- GSM8142304 Dnmt3a2_5d_Rep3 Dnmt3a2_5d
- GSM8142305 Dnmt3a2_5d_Rep4 Dnmt3a2_5d
- GSM8142306 Control_1d_Rep1 Control_1d
- GSM8142307 Control_1d_Rep2 Control_1d
- GSM8142308 Control_1d_Rep3 Control_1d
- GSM8142309 Control_1d_Rep4 Control_1d
- GSM8142310 Control_5d_Rep1 Control_5d
- GSM8142311 Control_5d_Rep2 Control_5d
- GSM8142312 Control_5d_Rep3 Control_5d
- GSM8142313 Control_5d_Rep4 Control_5d
- GSE224556 Z-DNA underlies the target choice of Aire by facilitating promoter poising [RNA-seq] 30 samples shares facilitating, promote
- GSE300871 Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization 18 samples shares stabilization, cortical
- GSE283112 Large-scale reorganization of DNA methylation and upregulation of extracellular matrix genes in cocaine reward-related hippocampal learning [RNA-seq] 10 samples shares hippocampal, methylation
- GSE220901 TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation 168 samples shares facilitating, promote
- GSE224557 Z-DNA underlies the target choice of Aire by facilitating promoter poising 78 samples shares facilitating, promote
- GSE295991 Transcription factor NFYA directs male meiotic entry by facilitating accessible chromatin at meiotic promoters in mice 32 samples shares facilitating, promote
- GSE295964 Transcription factor NFYA directs male meiotic entry by facilitating accessible chromatin at the promoters of genes expressed during meiosis [CUT&RUN] 13 samples shares facilitating, promote
- GSE304099 Sequential transcriptional gates in the thalamo-cortical circuit support memory stabilization [ChIP-seq] 13 samples shares stabilization, cortical
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.