A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma [RNAseq_Enasidenib_L2975_SW1353]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × L2975_DMSO vs 3 × L2975_ENASIDENIB vs 3 × SW1353_DMSO vs 3 × SW1353_ENASIDENIBGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcomaEBioMedicine · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261434_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1086938 and SRA study SRP494839. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8144069 L2975_DMSO_1 L2975_DMSO
- GSM8144070 L2975_DMSO_2 L2975_DMSO
- GSM8144071 L2975_DMSO_3 L2975_DMSO
- GSM8144072 L2975_ENASIDENIB_1 L2975_ENASIDENIB
- GSM8144073 L2975_ENASIDENIB_2 L2975_ENASIDENIB
- GSM8144074 L2975_ENASIDENIB_3 L2975_ENASIDENIB
- GSM8144075 SW1353_DMSO_1 SW1353_DMSO
- GSM8144076 SW1353_DMSO_2 SW1353_DMSO
- GSM8144077 SW1353_DMSO_3 SW1353_DMSO
- GSM8144078 SW1353_ENASIDENIB_1 SW1353_ENASIDENIB
- GSM8144079 SW1353_ENASIDENIB_2 SW1353_ENASIDENIB
- GSM8144080 SW1353_ENASIDENIB_3 SW1353_ENASIDENIB
- GSE235605 A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma [RNAseq_Enasidenib_T-CDS17#1] 6 samples shares idh2, chondrosarcoma, personalized, identifies, enasidenib, efficient
- GSE235701 A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma 29 samples shares idh2, chondrosarcoma, personalized, identifies, enasidenib, efficient
- GSE276347 Effect of modulation of microRNA-455-3p on gene expression in SW1353 human chondrosarcoma cells 12 samples shares sw1353, chondrosarcoma
- GSE289237 Effect of overexpression of HMGA2 in human chondrosarcoma SW1353 cell line overexpression and control cells. 6 samples shares sw1353, chondrosarcoma
- GSE280581 Intragenic Epigenetic Deregulation by IDH2 Mutations Synergizes with SRSF2 Mutations Causing Mis-splicing of Key Transcriptional Regulators [RNA-seq] 20 samples shares idh2
- GSE299161 MALNC: A new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response 15 samples shares idh2
- GSE242063 Effect on gene expression of knock down of Scrambled control or Kdm3b on wild-type or Idh2 R140Q TF-1 cells 9 samples shares idh2
- GSE24505 Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation 757 samples shares idh2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.