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Role of LARP7 in meiotic sex chromosome silencing

GSE261526 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/10/01 Platform GPL17021
Summary
Meiotic sex chromosome inactivation (MSCI) is an essential event in meiotic progression in mammalian spermatogenesis. We found that La Ribonucleoprotein 7 (LARP7) is involved in MSCI. LARP7 plays a role in fetal germ cells to promote their proliferation, but is once abolished in postnatal gonocytes and re-expresses in spermatocytes at the onset of meiosis. In spermatocytes, LARP7 localizes to the XY body, a compartmentalized chromatin domain on sex chromosomes. This study aimed to elucidate a possible function of LARP7 in the XY body by using germline-specific Larp7-deficient mice.
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Also filed as BioProject PRJNA1084272 and SRA study SRP493578. Searching any of these in the dataset finder brings you back here.

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