BPDCN MYB Fusions Regulate Cell Cycle Genes, Impair Differentiation and Induce Myeloid-Dendritic Cell Leukemia
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 124 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 124 samples: 23 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid-dendritic cell leukemiaJCI insight · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261536_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1088133 and SRA study SRP494759. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 70 samples.
How we read this: 23 replicated groups read from 124 sample titles; they account for 70 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8143630 MYB-WT, MYB
- GSM8143631 MYB-WT, H3K27ac
- GSM8143632 MYB-WT, V5Ab1 MYB-WT, V5Ab
- GSM8143633 MYB-WT, V5Ab2 MYB-WT, V5Ab
- GSM8143634 MYB-WT, IgG
- GSM8143635 MYB-TR, MYB
- GSM8143636 MYB-TR, H3K27ac
- GSM8143637 MYB-TR, V5Ab1 MYB-TR, V5Ab
- GSM8143638 MYB-TR, V5Ab2 MYB-TR, V5Ab
- GSM8143639 MYB-TR, IgG
- GSM8143640 MYB-PLEKHO1, MYB
- GSM8143641 MYB-PLEKHO1, H3K27ac
- GSM8143642 MYB-PLEKHO1, V5Ab1 MYB-PLEKHO1, V5Ab
- GSM8143643 MYB-PLEKHO1, V5Ab2 MYB-PLEKHO1, V5Ab
- GSM8143644 MYB-PLEKHO1, IgG
- GSM8143645 NTC, MYB
- GSM8143646 NTC, H3K27ac
- GSM8143647 NTC, V5Ab1 NTC, V5Ab
- GSM8143648 NTC, V5Ab2 NTC, V5Ab
- GSM8143649 NTC, IgG
- GSM8146197 CAL1, H3K27ac
- GSM8146198 CAL1, IgG
- GSM8146199 CAL1, MYB
- GSM8146200 pDC_01, H3K27ac
- GSM8146201 pDC_01, IgG
- GSM8146202 pDC_01, MYB
- GSM8146203 pDC_02, H3K27ac
- GSM8146204 pDC_02, IgG
- GSM8146205 pDC_02, MYB
- GSM8146206 pDC_03, H3K27ac
- GSM8146207 pDC_03, IgG
- GSM8146208 pDC_03, MYB
- GSM8146209 PDX_01, H3K27ac
- GSM8146210 PDX_01, IgG
- GSM8146211 PDX_02, H3K27ac
- GSM8146212 PDX_02, IgG
- GSM8146213 PDX_03, H3K27ac
- GSM8146214 PDX_03, IgG
- GSM8146215 PDX_04, H3K27ac
- GSM8146216 PDX_04, IgG
+ 84 more — browse all 124 samples with per-sample file links →
- GSE248326 The catalytic domain of SETD1B regulates H3K4me3 breadth and Myc expression in MLL-r leukemia 53 samples shares regulate, leukemia
- GSE296242 Sustained MYB activity drives emergent enhancer activation and precise enhancer-promoter interactions 81 samples shares myb
- GSE188412 The PAF1 Complex Regulates Transcriptional Termination and Reinitiation [CUT&Tag] 71 samples shares regulate
- GSE269958 Chromatin-associated LTR RNA m5C oxidation by TET2 regulates chromatin state and leukemogenesis [seq_DNA-ATAC_set2] 54 samples shares regulate
- GSE269959 Chromatin-associated LTR RNA m5C oxidation by TET2 regulates chromatin state and leukemogenesis [seq_DNA-CUTandTag] 41 samples shares regulate
- GSE241304 TET2 regulates histone H2AK119ub and leukemogenesis through LTR RNA m5C oxidation [seq_DNA-CUTandTag] 24 samples shares regulate
- GSE277367 The functional antagonism between SIRT2 and MOF regulates cell cycle progression and genome stability [ChIP-seq] 24 samples shares regulate
- GSE234078 A super-enhancer regulated RNA-binding protein cascade drives pancreatic cancer 24 samples shares regulate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.