Targeting Vdac2 overcomes immunotherapy resistance by inducing tumor cell death and inflammation
Expression microarray · human · 180 samples
- What it is
- Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
- Organism
- Homo sapiens (human)
- Samples
- 180 samples: 49 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
- Paper
- VDAC2 loss elicits tumour destruction and inflammation for cancer therapyNature · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261554_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.
Also filed as BioProject PRJNA1087429 and SRA study SRP495110. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 172 samples.
How we read this: 49 replicated groups read from 180 sample titles; they account for 172 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8144326 sgNTC_1 sgNTC
- GSM8144327 sgNTC_2 sgNTC
- GSM8144328 sgNTC_3 sgNTC
- GSM8144329 sgNTC_4 sgNTC
- GSM8144330 sgVdac2_1 sgVdac2
- GSM8144331 sgVdac2_2 sgVdac2
- GSM8144332 sgVdac2_3 sgVdac2
- GSM8144333 sgVdac2_4 sgVdac2
- GSM8144334 sgNTC_OTI_1 sgNTC_OTI
- GSM8144335 sgNTC_OTI_2 sgNTC_OTI
- GSM8144336 sgNTC_OTI_3 sgNTC_OTI
- GSM8144337 sgNTC_OTI_4 sgNTC_OTI
- GSM8144338 sgVdac2OTI_1 sgVdac2OTI
- GSM8144339 sgVdac2OTI_2 sgVdac2OTI
- GSM8144340 sgVdac2OTI_3 sgVdac2OTI
- GSM8144341 sgVdac2OTI_4 sgVdac2OTI
- GSM8146485 WT_0h 1 WT_0h
- GSM8146486 WT_0h 2 WT_0h
- GSM8146487 WT_0h 3 WT_0h
- GSM8146488 WT_0h 4 WT_0h
- GSM8146489 KO_0h 1 KO_0h
- GSM8146490 KO_0h 2 KO_0h
- GSM8146491 KO_0h 3 KO_0h
- GSM8146492 KO_0h 4 KO_0h
- GSM8146493 WT_4h 1 WT_4h
- GSM8146494 WT_4h 2 WT_4h
- GSM8146495 WT_4h 3 WT_4h
- GSM8146496 WT_4h 4 WT_4h
- GSM8146497 KO_4h 1 KO_4h
- GSM8146498 KO_4h 2 KO_4h
- GSM8146499 KO_4h 3 KO_4h
- GSM8146500 KO_4h 4 KO_4h
- GSM8146501 WT_8h 1 WT_8h
- GSM8146502 WT_8h 2 WT_8h
- GSM8146503 WT_8h 3 WT_8h
- GSM8146504 WT_8h 4 WT_8h
- GSM8146505 KO_8h 1 KO_8h
- GSM8146506 KO_8h 2 KO_8h
- GSM8146507 KO_8h 3 KO_8h
- GSM8146508 KO_8h 4 KO_8h
+ 140 more — browse all 180 samples with per-sample file links →
- GSE266391 Suppressing Aberrant Hedgehog Pathway and Overcoming Resistance to Smoothened Antagonists via Targeting Super-enhancer-driven Transcriptional Dependencies 74 samples shares resistance, targeting
- GSE266389 Suppressing Aberrant Hedgehog Pathway and Overcoming Resistance to Smoothened Antagonists via Targeting Super-enhancer-driven Transcriptional Dependencies [RNA-seq] 60 samples shares resistance, targeting
- GSE274229 Evolution of myeloid-mediated immunotherapy resistance in prostate cancer 52 samples shares immunotherapy, resistance
- GSE266364 Immunogenic cell death inducer cEmsy boosted cancer immunotherapy in lung adenocarcinoma 33 samples shares immunotherapy, death
- GSE342640 Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation 159 samples shares resistance
- GSE218392 Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis 120 samples shares targeting
- GSE52947 Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice 118 samples shares targeting
- GSE279644 BCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs [ChIP-Seq] 91 samples shares targeting
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.