Neutrophil transcriptome in community acquired pneumonia and age matched controls
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 7 × Neutrophil,CAP, vs 7 × Neutrophil, Control,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hospitalised older adults with community-acquired pneumonia and sepsis have dysregulated neutrophil function but preserved glycolysisThorax · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261559_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1087440 and SRA study SRP495118. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 2 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8146650 Neutrophil,CAP,1 Neutrophil,CAP,
- GSM8146651 Neutrophil,CAP,2 Neutrophil,CAP,
- GSM8146652 Neutrophil,CAP,3 Neutrophil,CAP,
- GSM8146653 Neutrophil,CAP,4 Neutrophil,CAP,
- GSM8146654 Neutrophil,CAP,5 Neutrophil,CAP,
- GSM8146655 Neutrophil,CAP,6 Neutrophil,CAP,
- GSM8146656 Neutrophil,CAP,7 Neutrophil,CAP,
- GSM8146657 Neutrophil, Control,1 Neutrophil, Control,
- GSM8146658 Neutrophil, Control,2 Neutrophil, Control,
- GSM8146659 Neutrophil, Control,3 Neutrophil, Control,
- GSM8146660 Neutrophil, Control,4 Neutrophil, Control,
- GSM8146661 Neutrophil, Control,5 Neutrophil, Control,
- GSM8146662 Neutrophil, Control,6 Neutrophil, Control,
- GSM8146663 Neutrophil, Control,7 Neutrophil, Control,
- GSE228541 Integrated analysis of messenger RNA and microRNA in patients with community-acquired pneumonia associated sepsis (mRNA part) 29 samples shares community, pneumonia, acquired
- GSE309422 RNAseq analysis of human neutrophil mRNA from adults with SLE and age-matched healthy controls 21 samples shares neutrophil, controls, matched
- GSE302306 Transcriptomic Profiling of CD66b+ Neutrophils from Healthy Controls and Cardiac Surgery Patients with Vasoplegic and Septic Shock Syndromes Across Multiple Timepoints 68 samples shares neutrophil, controls
- GSE292338 RNAseq analysis of human neutrophils from healthy controls, people with frailty and people with rheumatoid arthritis 39 samples shares neutrophil, controls
- GSE293224 RNAseq analysis of human neutrophils from healthy controls and from people with systemic lupus eruthematosus 35 samples shares neutrophil, controls
- GSE259282 Calcineurin-NFAT signaling controls the neutrophils´ ability of chemoattraction upon fungal infection. 24 samples shares neutrophil, controls
- GSE288904 Transcriptome Sequencing Data of Peripheral Blood Neutrophils in Multiple Sclerosis Patients and Healthy Volunteers 37 samples shares neutrophil
- GSE225061 Combination of a SOS1-KRAS interaction inhibitor with a KRASG12C inhibitor combination can address intrinsic and acquired resistance leading to stronger and more durable response 217 samples shares acquired
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.