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RNAseq analysis of human neutrophils from healthy controls, people with frailty and people with rheumatoid arthritis

GSE292338 Homo sapiens (human) RNA-seq (gene expression) 39 samples Submitted 2026/03/09 Platform GPL28038
At a glance

RNA-seq (gene expression) · human · 39 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
39 samples: 10 × Blood neutrophil, 0h, Frailty, vs 10 × Blood neutrophil, 0h, Healthy young, vs 10 × Blood neutrophil, 0h, Rheumatoid arthritis, vs 9 × Blood neutrophil, 0h, Healthy old,Groups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailtyClinical and experimental immunology · 2026
Summary (written by the submitters)
We report gene expression profiles of blood neutrophils from (1) people with frailty (2) healthy older people (>60Y), (3) healthy younger people (18-25Y), (4) people with rheumatoid arthritis.
Published in
Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty
Abdullah GA, Walsh J, Sellin A et al. · Clinical and experimental immunology 2026 · PMID 41906686 · doi:10.1093/cei/uxag019
This dataset
Open GSE292338 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE292338_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1238189 and SRA study SRP571514. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41906686) ↗
Study design
10 × Blood neutrophil, 0h, Frailty, vs 10 × Blood neutrophil, 0h, Healthy young, vs 10 × Blood neutrophil, 0h, Rheumatoid arthritis, vs 9 × Blood neutrophil, 0h, Healthy old,

Supports a between-group comparison across 39 samples.

How we read this: 4 replicated groups read from 39 sample titles; they account for 39 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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