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Hippo deficient cardiac fibroblasts differentiate into osteochondroprogenitors (ST)

GSE261640 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/07 Platform GPL24247
Summary
We investigated how Hippo-deficient cardiac fibroblasts (CFs) alter their cell state and interact with immune cells during cardiac fibrosis. To study the role of the Hippo pathway in CFs, we conditionally knocked out Lats1/2 specifically in the CFs of mouse hearts (Lats1/2CKO). To test the role of Hippo-deficient CF-induced macrophages, we treated the control and Lats1/2CKO mice with or without CSF1R inhibitor to block macrophage expansion and performed ST.
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Also filed as BioProject PRJNA1088152 and SRA study SRP495319. Searching any of these in the dataset finder brings you back here.

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