Hippo deficient cardiac fibroblasts promote atrial remodeling
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261643_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1088149 and SRA study SRP495315. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8147800 Control
- GSM8147801 Lats1/2CKO
- GSM8147802 Lats1/2CKO + Csf1r Inhibitor
- GSM8147803 Lats1/2CKO + Vehicle
- GSM8147804 Control + Csf1r Inhibitor
- GSM8147805 Control + Vehicle
- GSM8147806 Control male right atrium
- GSM8147807 Control female right atrium
- GSM8147808 Lats1/2CKO male right atrium
- GSM8147809 Lats1/2CKO female right atrium
- GSM8147810 Control male left atrium
- GSM8147811 Control female left atrium
- GSM8147812 Lats1/2CKO male left atrium
- GSM8147813 Lats1/2CKO female left atrium
- GSM8149581 Control right atrium with Csf1r inhibitor injection (snRNA only)
- GSM8149582 Lats1/2CKO right atrium with Csf1r inhibitor injection (snRNA only)
- GSM8149583 Control right atrium with vehicle injection (snMultiomics-RNA)
- GSM8149584 Control right atrium with Csf1r inhibitor injection (snMultiomics-RNA)
- GSM8149585 Lats1/2CKO right atrium with vehicle injection (snMultiomics-RNA)
- GSM8149586 Lats1/2CKO right atrium with Csf1r inhibitor injection (snMultiomics-RNA)
- GSM8149587 Control right atrium with vehicle injection (snMultiomics-ATAC)
- GSM8149588 Control right atrium with Csf1r inhibitor injection (snMultiomics-ATAC)
- GSM8149589 Lats1/2CKO right atrium with vehicle injection (snMultiomics-ATAC)
- GSM8149590 Lats1/2CKO right atrium with Csf1r inhibitor injection (snMultiomics-ATAC)
- GSE267256 Bulk RNA-seq analysis reveals the crucial role of Collagen triplex helix repeat containing-1 (Cthrc1) cardiac fibroblasts for ventricular remodeling after myocardial infarction 17 samples shares fibroblasts, remodeling, cardiac
- GSE298401 A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling 40 samples shares remodeling, cardiac
- GSE306718 Macrophage Cluster of Differentiation 163 promotes post-infarction cardiac repair and preserves left ventricular function via osteopontin 37 samples shares cardiac, promote
- GSE279927 RNA next-generation sequencing of cardiac fibroblasts isolated from young and old mice 7 days post-MI 25 samples shares fibroblasts, cardiac
- GSE327565 Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling 14 samples shares remodeling, promote
- GSE307681 Dermal fibroblasts respond to interleukin-4 and 13 and promote T-cell recruitment in atopic dermatitis 12 samples shares fibroblasts, promote
- GSE330351 Ferritin-mediated iron homeostasis regulates fibroblast activation and shapes post-infarction cardiac remodeling 9 samples shares remodeling, cardiac
- GSE267452 Loss of Nuclear Receptor Nr4a3 Alleviates Cellular Senescence to Promote Adult Direct Cardiac Reprogramming 54 samples shares cardiac, promote
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.