GEO series
Hippo deficient cardiac fibroblasts differentiate into osteochondroprogenitors (snMultiomics)
GSE261719
Mus musculus
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
10 samples
2025/10/07
GPL24247
Summary
We investigated how Hippo deficient CFs alter their cell state and interact with immune cells during cardiac fibrosis. To study the role of the Hippo pathway in CFs, we conditionally knocked out Lats1/2 specifically in the CFs of mouse hearts (Lats1/2-CF) and performed single-nucleus RNA sequencing (snRNA-seq) and single-nucleus multiomics to profile the cellular landscape of the right atria, with and without Csf1r inhibitor
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