Convergent transcriptomic signatures across brain structures in eating disorders and obsessive compulsive disorder
RNA-seq (gene expression) · human · 338 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 338 samples: 170 × control, vs 114 × ED, vs 54 × OCD,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Convergent molecular signatures across eating disorders and obsessive-compulsive disorder in the human brainmedRxiv : the preprint server for health sciences · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262138_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1090459 and SRA study SRP496996. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 338 samples.
How we read this: 3 replicated groups read from 338 sample titles; they account for 338 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8158113 ED, R10526 ED,
- GSM8158114 OCD, R10537 OCD,
- GSM8158115 ED, R10540 ED,
- GSM8158116 ED, R10592 ED,
- GSM8158117 ED, R11276 ED,
- GSM8158118 ED, R11313 ED,
- GSM8158119 ED, R11317 ED,
- GSM8158120 ED, R11362 ED,
- GSM8158121 ED, R11371 ED,
- GSM8158122 OCD, R11380 OCD,
- GSM8158123 OCD, R11382 OCD,
- GSM8158124 control, R11384 control,
- GSM8158125 control, R11544 control,
- GSM8158126 control, R11558 control,
- GSM8158127 control, R11569 control,
- GSM8158128 control, R11632 control,
- GSM8158129 ED, R11852 ED,
- GSM8158130 ED, R11870 ED,
- GSM8158131 ED, R11891 ED,
- GSM8158132 OCD, R11987 OCD,
- GSM8158133 ED, R11988 ED,
- GSM8158134 ED, R12062 ED,
- GSM8158135 OCD, R12066 OCD,
- GSM8158136 OCD, R12081 OCD,
- GSM8158137 control, R12087 control,
- GSM8158138 control, R12096 control,
- GSM8158139 control, R12323 control,
- GSM8158140 control, R12344 control,
- GSM8158141 control, R12347 control,
- GSM8158142 control, R12362 control,
- GSM8158143 control, R12368 control,
- GSM8158144 control, R12381 control,
- GSM8158145 control, R12384 control,
- GSM8158146 control, R12408 control,
- GSM8158147 control, R12443 control,
- GSM8158148 control, R12447 control,
- GSM8158149 control, R12481 control,
- GSM8158150 control, R12510 control,
- GSM8158151 control, R12522 control,
- GSM8158152 control, R12525 control,
+ 298 more — browse all 338 samples with per-sample file links →
- GSE272200 Differential gene expression in thalamic postmortem tissue of subjects with obsessive compulsive disorder 85 samples shares compulsive, obsessive, disorder
- GSE328351 Bulk RNA-seq of dorsolateral prefrontal cortex tissue collected during deep brain stimulation neurosurgery in obsessive-compulsive disorder and neurological controls 10 samples shares compulsive, obsessive, disorder
- GSE290695 Identification of Crohn’s disease subtypes in single cell RNA sequencing signatures of treatment naïve samples across the gastrointestinal tract 95 samples shares signatures, across
- GSE281069 Mapping the glial transcriptome in Huntington’s disease using snRNAseq: Selective disruption of glial signatures across brain regions 44 samples shares signatures, across
- GSE233321 Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures 118 samples shares signatures, across
- GSE319461 DNA methylation stochasticity is linked to transcriptional variability and identifies convergent epigenetic disruption across genetically-defined subtypes of AML 82 samples shares convergent, across
- GSE298243 Single-Cell Profiling of DNA Methylation in Autism Spectrum Disorder Prefrontal Cortex Reveals Distinct Regulatory and Aging Signatures 49 samples shares signatures, disorder
- GSE319444 DNA methylation stochasticity is linked to transcriptional variability and identifies convergent epigenetic disruption across genetically-defined subtypes of AML [PrimaryAML_WGBS] 20 samples shares convergent, across
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.