GEO series
Effect of TOP2B deletion or catalytic inhibition on gene expression in iPSC-derived human cardiomyocytes
GSE262148
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2025/07/24
GPL24676
Summary
DNA topoisomerase IIB (TOP2B) is required for the correct execution of certain developmental transcription programs. Here, we have compared the transcriptional changes accompanying differentiation of wild type and TOP2B null human iPSC cells to beating cardiomyocytes. In addition we assess the transcriptional effect of short term (3hr) application of two TOP2B catalytic inhibitors in iPSC-derived cardiomyocytes.
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