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Generation of synthetic kidneys from expandable kidney progenitors [Days 5 and 9]

GSE262462 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/04/25 Platform GPL24247
Summary
Kidney is the central organs responsible for maintaining the homeostasis of our body, the sophisticated structure and cell composition underpin kidney’s function. Here we report the generation of mouse synthetic kidneys (SK) from expandable nephron progenitor cells (NPC) and ureteric bud (UB). Unexpectedly, versatile renal interstitial cells can be induced in synthetic kidneys. Mechanistically, a portion of NPCs go through transdifferentiation and become interstitial progenitor cells (IPCs) in SK context, then further differentiate into various renal interstitial cells. These kidney progenitors-derived synthetic kidneys highly resembled postnatal mouse kidneys in terms of high-order patterning and showed essential renal physiological functions.
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Also filed as BioProject PRJNA1091921 and SRA study SRP497868. Searching any of these in the dataset finder brings you back here.

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