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Effect of GSK3 inhibition on the transcriptional signature of human alveolar macrophages

GSE262463 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/16 Platform GPL23227
Summary
The remarkable plasticity of macrophages is tied to extracelular cues and their subsequently signaling pathways. The transcriptional factor MAFB is critical to prompt the aquisition of an anti-inflammatory phenotype in macrophages. As MAFB activity and stability is highly regulated by GSK3, we explored the molecular impact of blocking GSK3 on the gene expression profile of human alveolar macrophages (AMØ), whose development and gene expression profile is GM-CSF-dependent. GSK3 inhibition skewed the transcriptional profile of AMØ towards an anti-inflammatory phenotype.
Published in
Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation
Ríos I, Herrero C, Torres-Torresano M et al. · eLife 2025 · PMID 40365863 · doi:10.7554/eLife.102659
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Also filed as BioProject PRJNA1091920 and SRA study SRP497875. Searching any of these in the dataset finder brings you back here.

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