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Single Nuclei sequencing of mouse model of MBL1 and 2 KD

GSE262646 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/07/15 Platform GPL24247
Summary
This study looks at a new model of MBL1 and MBL1 KD to understand how these proteins funciton in muscle development and contribute for DM1 pathology. Animals were injected into the tibialis anterior (TA) muscle at 10 weeks of age. Sampling was performed approximately 10 weeks after injection, i.e. at around 20 weeks of age. The left TA was injected with an AAV encoding shmir directed against Mbnl1 and Mbnl2, and the left TA was injected with an AAV encoding shmir directed against LacZ (control). Both muscles were therefore injected with AAV.
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Direct links to NCBI, no account and no request form: the whole study as GSE262646_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1092697 and SRA study SRP498294. Searching any of these in the dataset finder brings you back here.

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