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The role of inflammatory macrophages in pathophysiology of experimental autoimmune myocarditis

GSE262658 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/06/20 Platform GPL24247
Summary
Myocarditis is an inflammatory disease of the cardiac muscle characterized by an influx of inflammatory cells, predominantly of myeloid lineage. The progression of myocarditis to a dilated cardiomyopathy phenotype and heart failure is markedly influenced by TGF-β signalling. The aim of this study was to investigate the role of TGF-β signalling in inflammatory cardiac macrophages in the development of myocarditis and post-inflammatory fibrosis. Experimental autoimmune myocarditis (EAM) was induced in the LysM-Cre x R26-stop-EYFP x Tgfbr2-fl/fl transgenic mice showing impaired TGF-β signalling in the myeloid lineage and the LysM-Cre x R26-stop-EYFP control mice. Inflammatory macrophages were sorted from the inflamed hearts and analyzed for differential gene expression using whole genome transcriptomics.
Published in
TGF-β Signalling Regulates Cytokine Production in Inflammatory Cardiac Macrophages during Experimental Autoimmune Myocarditis
Tkacz K, Rolski F, Stefańska M et al. · International journal of molecular sciences 2024 · PMID 38891767 · doi:10.3390/ijms25115579
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Also filed as BioProject PRJNA1092732 and SRA study SRP499484. Searching any of these in the dataset finder brings you back here.

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