GEO series
A role for astrocytic miR-129-5p in Frontotemporal Dementia
GSE262895
Mus musculus (mouse)
RNA-seq (gene expression)
32 samples
Submitted 2025/04/17
Platform GPL13112
At a glance
RNA-seq (gene expression) · mouse · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 32 samples: 7 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A role for astrocytic miR-129-5p in frontotemporal dementiaTranslational psychiatry · 2025
Summary (written by the submitters)
Frontotemporal dementia is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe degeneration, resulting in behavioral changes, language difficulties, and cognitive decline. In this study, smallRNA sequencing was conducted on postmortem brain tissues obtained from FTD patients with GRN, MAPT, or C9ORF mutations, focusing on the frontal and temporal lobes.
Read the full summary ↓
Our analysis identified miR-129-5p as consistently deregulated across all mutation conditions and brain regions. Functional investigations revealed a novel role of miR-129-5p in astrocytes, where its loss led to neuroinflammation and impaired neuronal support functions, including glutamate uptake. Depletion of miR-129-5p in astrocytes resulted in the loss of neuronal spines and altered neuronal network activity. These findings highlight miR-129-5p as a potential therapeutic target in neurodegenerative diseases and also sheds light on the role of astrocytes in Frontotemporal dementia pathogenesis.
Published in
Kaurani L, Pradhan R, Schröder S et al.
· Translational psychiatry 2025
· PMID 40216778
· doi:10.1038/s41398-025-03338-y
This dataset
Download · which file do I need?
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
1 · Just have a look
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
2 · Re-analyse it
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262895_RAW.tar (it can run to tens of gigabytes).
3 · Start from the raw reads
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1094590 and SRA study SRP498902. Searching any of these in the dataset finder brings you back here.
Study design
7 conditions, mostly with about 5 replicates each
RNA sequencing from primary neurons_sc-control ×6
RNA sequencing from primary astrocytes_sc-con… ×5
RNA-sequencing from mouse primary cortical ne… ×5
RNA sequencing from primary neurons_anti-miR-… ×5
RNA sequencing from primary astrocytes_anti-m… ×4
RNA-sequencing from mouse primary cortical ne… ×4
RNA sequencing from primary astrocytes anti-m… ×2
RNA sequencing from primary astrocytes sc-con… ×1
Supports a between-group comparison across 31 samples.
How we read this: 7 replicated groups read from 32 sample titles; they account for 31 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
Samples in this study
- GSM8181195 RNA sequencing from primary astrocytes anti-miR-129_1 RNA sequencing from pri…
- GSM8181196 RNA sequencing from primary astrocytes sc-control_1
- GSM8181197 RNA sequencing from primary astrocytes anti-miR-129_2 RNA sequencing from pri…
- GSM8181198 RNA sequencing from primary astrocytes_sc-control_2 RNA sequencing from pri…
- GSM8181199 RNA sequencing from primary astrocytes_anti-miR-129_3 RNA sequencing from pri…
- GSM8181200 RNA sequencing from primary astrocytes_sc-control_3 RNA sequencing from pri…
- GSM8181201 RNA sequencing from primary astrocytes_anti-miR-129_4 RNA sequencing from pri…
- GSM8181202 RNA sequencing from primary astrocytes_sc-control_4 RNA sequencing from pri…
- GSM8181203 RNA sequencing from primary astrocytes_anti-miR-129_5 RNA sequencing from pri…
- GSM8181204 RNA sequencing from primary astrocytes_sc-control_5 RNA sequencing from pri…
- GSM8181205 RNA sequencing from primary astrocytes_anti-miR-129_6 RNA sequencing from pri…
- GSM8181206 RNA sequencing from primary astrocytes_sc-control_6 RNA sequencing from pri…
- GSM8181207 RNA-sequencing from mouse primary cortical neurons co-culture with mouse primary astrocytes_sc-control_1 RNA-sequencing from mou…
- GSM8181208 RNA-sequencing from mouse primary cortical neurons co-culture with mouse primary astrocytes_anti-miR-129_1 RNA-sequencing from mou…
- GSM8181209 RNA-sequencing from mouse primary cortical neurons co-culture with mouse primary astrocytes_sc-control_2 RNA-sequencing from mou…
- GSM8181210 RNA-sequencing from mouse primary cortical neurons co-culture with mouse primary astrocytes_anti-miR-129_2 RNA-sequencing from mou…
- GSM8181211 RNA-sequencing from mouse primary cortical neurons co-culture with mouse primary astrocytes_sc-control_3 RNA-sequencing from mou…
- GSM8181212 RNA-sequencing from mouse primary cortical neurons co-culture with mouse primary astrocytes_anti-miR-129_3 RNA-sequencing from mou…
- GSM8181213 RNA-sequencing from mouse primary cortical neurons co-culture with mouse primary astrocytes_sc-control_4 RNA-sequencing from mou…
- GSM8181214 RNA-sequencing from mouse primary cortical neurons co-culture with mouse primary astrocytes_anti-miR-129_4 RNA-sequencing from mou…
- GSM8181215 RNA-sequencing from mouse primary cortical neurons co-culture with mouse primary astrocytes_anti-miR-129_5 RNA-sequencing from mou…
- GSM8181216 RNA sequencing from primary neurons_sc-control_1 RNA sequencing from pri…
- GSM8181217 RNA sequencing from primary neurons_anti-miR-129_1 RNA sequencing from pri…
- GSM8181218 RNA sequencing from primary neurons_sc-control_2 RNA sequencing from pri…
- GSM8181219 RNA sequencing from primary neurons_anti-miR-129_2 RNA sequencing from pri…
- GSM8181220 RNA sequencing from primary neurons_sc-control_3 RNA sequencing from pri…
- GSM8181221 RNA sequencing from primary neurons_anti-miR-129_3 RNA sequencing from pri…
- GSM8181222 RNA sequencing from primary neurons_sc-control_4 RNA sequencing from pri…
- GSM8181223 RNA sequencing from primary neurons_sc-control_5 RNA sequencing from pri…
- GSM8181224 RNA sequencing from primary neurons_anti-miR-129_4 RNA sequencing from pri…
- GSM8181225 RNA sequencing from primary neurons_sc-control_6 RNA sequencing from pri…
- GSM8181226 RNA sequencing from primary neurons_anti-miR-129_5 RNA sequencing from pri…
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Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.