Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress
RNA-seq (gene expression) · mouse · 39 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 39 samples: 6 conditions, mostly with about 7 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284730_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1200132 and SRA study SRP552483. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 39 samples.
How we read this: 6 replicated groups read from 39 sample titles; they account for 39 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8691399 Control, PFC, sample 1 Control, PFC, sample
- GSM8691400 Control, NAC, sample 2 Control, NAC, sample
- GSM8691401 Susceptible, PFC, sample 3 Susceptible, PFC, sample
- GSM8691402 Susceptible, NAC, sample 4 Susceptible, NAC, sample
- GSM8691403 Resilient, PFC, sample 5 Resilient, PFC, sample
- GSM8691404 Control, PFC, sample 7 Control, PFC, sample
- GSM8691405 Control, NAC, sample 8 Control, NAC, sample
- GSM8691406 Susceptible, PFC, sample 9 Susceptible, PFC, sample
- GSM8691407 Susceptible, NAC, sample 10 Susceptible, NAC, sample
- GSM8691408 Resilient, PFC, sample 11 Resilient, PFC, sample
- GSM8691409 Resilient, NAC, sample 12 Resilient, NAC, sample
- GSM8691410 Control, NAC, sample 14 Control, NAC, sample
- GSM8691411 Resilient, PFC, sample 15 Resilient, PFC, sample
- GSM8691412 Resilient, NAC, sample 16 Resilient, NAC, sample
- GSM8691413 Control, PFC, sample 17 Control, PFC, sample
- GSM8691414 Control, NAC, sample 18 Control, NAC, sample
- GSM8691415 Susceptible, NAC, sample 20 Susceptible, NAC, sample
- GSM8691416 Resilient, NAC, sample 22 Resilient, NAC, sample
- GSM8691417 Susceptible, NAC, sample 24 Susceptible, NAC, sample
- GSM8691418 Resilient, NAC, sample 26 Resilient, NAC, sample
- GSM8691419 Control, PFC, sample 27 Control, PFC, sample
- GSM8691420 Control, NAC, sample 28 Control, NAC, sample
- GSM8691421 Susceptible, PFC, sample 29 Susceptible, PFC, sample
- GSM8691422 Susceptible, NAC, sample 30 Susceptible, NAC, sample
- GSM8691423 Resilient, PFC, sample 31 Resilient, PFC, sample
- GSM8691424 Resilient, NAC, sample 32 Resilient, NAC, sample
- GSM8691425 Control, PFC, sample 33 Control, PFC, sample
- GSM8691426 Control, NAC, sample 34 Control, NAC, sample
- GSM8691427 Susceptible, PFC, sample 35 Susceptible, PFC, sample
- GSM8691428 Susceptible, NAC, sample 36 Susceptible, NAC, sample
- GSM8691429 Resilient, NAC, sample 38 Resilient, NAC, sample
- GSM8691430 Control, PFC, sample 39 Control, PFC, sample
- GSM8691431 Control, NAC, sample 40 Control, NAC, sample
- GSM8691432 Susceptible, PFC, sample 41 Susceptible, PFC, sample
- GSM8691433 Susceptible, NAC, sample 42 Susceptible, NAC, sample
- GSM8691434 Resilient, PFC, sample 43 Resilient, PFC, sample
- GSM8691435 Resilient, NAC, sample 44 Resilient, NAC, sample
- GSM8691436 Susceptible, PFC, sample 47 Susceptible, PFC, sample
- GSM8691437 Susceptible, NAC, sample 48 Susceptible, NAC, sample
- GSE268460 Chronic stress deficits in reward behaviour co-occur with low nucleus accumbens dopamine activity during reward anticipation specifically 11 samples shares accumbens, chronic, stress
- GSE315159 Nucleus accumbens neuron subtype translatome signatures in socially stressed females 30 samples shares accumbens, stress
- GSE330309 Impact of Sex Chromosomes and Gonad Type in Stress Susceptibility in Corticostriatal Brain Regions 96 samples shares susceptibility, stress
- GSE233419 Monomethylation of Lysine 27 at Histone 3 Confers Lifelong Susceptibility to Stress 72 samples shares susceptibility, stress
- GSE324816 Amygdala engram ensembles mediate differential susceptibility to short-term negative stress-induced remote depression in adolescent and adult mice 32 samples shares susceptibility, stress
- GSE270456 PHF6 regulates stress susceptibility in the pituitary intermediate lobe [RNA-seq] 24 samples shares susceptibility, stress
- GSE251656 Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice [RNA-seq] 12 samples shares susceptibility, stress
- GSE315845 Primary Cilia Mediate Stress Vulnerability and Exercise Antidepressant Adaptation: Evidence for Ventral Hippocampal Astrocytic Ciliary Remodeling by Exercise 9 samples shares astrocytic, stress
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.