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Effect of FN14KO on mouse lung immune cells after bleomycin injury

GSE262928 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/20 Platform GPL24247
Summary
TWEAK, also known as TNFSF12, is a multifunctional cytokine that controls many cellular activities in tissue repair and disease by binding to its receptor Fn14.TWEAK-Fn14 signaling has been shown to induce canonical and noncanonical NFkB signaling, triggering pro-inflammatory responses and leukocyte infiltration.In the bleomycin-induced lung fibrosis model, Fn14 KO mice were found to induce a more severe fibrotic phenotype. To explore the effect of Fn14 KO on immune cell populations in this model, we performed single-cell sequencing.
Published in
TWEAK-Fn14 signaling protects mice from pulmonary fibrosis by inhibiting fibroblast activation and recruiting pro-regenerative macrophages
Liu L, Wu P, Wei Y et al. · Cell reports 2025 · PMID 39827460 · doi:10.1016/j.celrep.2024.115220
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Also filed as BioProject PRJNA1094932 and SRA study SRP499019. Searching any of these in the dataset finder brings you back here.

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