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Gene expression profile at single cell level of CD4+ T cells from the lymph nodes of young and old DBA/1 mice with or without glucose-6-phosphate isomerase (GPI)-induced arthritis (GIA)

GSE263231 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/08/19 Platform GPL21273
Summary
It has been suggested that CD4+ T cell senescence is involved in the pathogenesis of elderly-onset rheumatoid arthritis (EORA). We performed scRNA-seq analysis using CD4+ T cells collected from inguinal lymph nodes of young and old DBA/1 mice to investigate the association between aging CD4+ T cells and elderly-onset arthritis.
Published in
Mechanisms of age-related Treg dysfunction in an arthritic environment
Nishiyama T, Ohyama A, Miki H et al. · Clinical immunology (Orlando, Fla.) 2024 · PMID 39111562 · doi:10.1016/j.clim.2024.110337
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Also filed as BioProject PRJNA1096322 and SRA study SRP499816. Searching any of these in the dataset finder brings you back here.

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