Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis [LKO_NASH]
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasisHepatology (Baltimore, Md.) · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE218073_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA902276 and SRA study SRP408210. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6734249 Liver_CON_NASH_1 [A54N]
- GSM6734250 Liver_CON_NASH_2 [A55R]
- GSM6734251 Liver_CON_NASH_3 [A55L]
- GSM6734252 Liver_CON_NASH_4 [A55B]
- GSM6734253 Liver_CON_NASH_5 [A55RLL]
- GSM6734254 Liver_LKO_NASH_1 [A54R]
- GSM6734255 Liver_LKO_NASH_2 [A54L]
- GSM6734256 Liver_LKO_NASH_3 [A67N]
- GSM6734257 Liver_LKO_NASH_4 [A67R]
- GSM6734258 Liver_LKO_NASH_5 [A67L]
- GSE218075 Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis. 18 samples shares steatohepatitis, mitochondrial, phospholipid, nonalcoholic, progression, homeostasis
- GSE256502 Sex differences in Non-Alcoholic Steatohepatitis (NASH) in mice evoked by a fructose-palmitate-cholesterol (FPC)-enriched diet [bulk_isolated_cells] 31 samples shares nash, steatohepatitis
- GSE274650 G3BP1 translocates into mitochondria to impair MCU complex function and promotes NASH progression [G3bp1-HKO and G3bp1-Flox mice with BSA or PA treatment] 12 samples shares nash, progression
- GSE264479 LIX1L aggravates NASH-HCC progression by reprogramming of hepatic Metabolism and microenvironment via CD36 12 samples shares nash, progression
- GSE256501 Sex differences in Non-Alcoholic Steatohepatitis (NASH) in mice evoked by a fructose-palmitate-cholesterol (FPC)-enriched diet [bulk_liver] 12 samples shares nash, steatohepatitis
- GSE263273 Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis 28 samples shares steatohepatitis, nonalcoholic
- GSE225414 Mitochondrial regulation of bone homeostasis via mitochondria transfer [RNA-seq] 18 samples shares mitochondrial, homeostasis
- GSE328769 Alzheimer's disease associated Presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor Gbf1 16 samples shares mitochondrial, homeostasis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.