← BioTransfer GEO Dataset Finder
GEO series

Role of reactive oxygen species on the intestinal macrophages development

GSE263475 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/08/13 Platform GPL24247
Summary
Chronic granulomatous disease (CGD) is an immunodeficiency disease caused by defects in any one of the five structural components of the NADPH oxidase enzyme, i.e. X-linked reces-sive mutations in CYBB (gp91phox), or autosomal recessive mutations in CYBA (p22phox), NCF1 (p47phox), NCF2 (p67phox), NCF4 (p40phox). CGD results from reduced or absent reactive oxygen species (ROS) production. ROS play a crucial role in phagocytes; therefore, CGD patients are less capable to kill pathogens. I addition, and at the heart of this project proposal, around 50 % of patients with CGD suffer from severe intestinal inflammation which shares features with inflammatory bowel disease, according to a report of the National Institutes of Health. However, the molecular and cellular mechanisms underlying CGD colitis are largely unknown. Our hypotheses is that CGD is associated colitis involves dysregulation of resident intestinal macrophages.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE263475_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1095817 and SRA study SRP500244. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.