GEO series
Bulk RNA-seq of microglia from Apoa1 KO mice injected with ApoA-I protein intravenously
GSE264111
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2024/10/15
GPL21626
Summary
We found ApoA-I from blood can be taken up by microglia in the brain. To determine if ApoA-I from circulation is sufficient to restore microglial transcriptomic state to a more wild-type-like state, we performed a rescue experiment by intravenously injecting ApoA-I protein into adult Apoa1 KO mice and sorted microglia with or without ApoA-I uptake for bulk transcriptomic analysis.
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