GEO series
Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer
GSE264145
Homo sapiens; Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/06/21
GPL24247GPL24676
Summary
We discovered, through mining TCGA data and conducting CRISPR screens, that DUSP18 expression within tumor cells significantly influences the immune microenvironment of colorectal cancer.To explore the role of DUSP18 in regulating the immune microenvironment of colorectal cancer (CRC), we established MC38 and HCT116 cell lines with targeted gene knockdown via shRNA and performed RNA-Seq.
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Paper (PMID 38992029) ↗
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