Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity
DNA methylation · human · 203 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 203 samples: 69 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264730_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1103851 and SRA study SRP503553. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 187 samples.
How we read this: 69 replicated groups read from 203 sample titles; they account for 187 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8224288 RNA-seq, SNU1079 in vitro, DMSO, Replicate 1 RNA-seq, SNU1079 in vit…
- GSM8224289 RNA-seq, SNU1079 in vitro, DMSO, Replicate 2 RNA-seq, SNU1079 in vit…
- GSM8224290 RNA-seq, SNU1079 in vitro, DMSO, Replicate 3 RNA-seq, SNU1079 in vit…
- GSM8224291 RNA-seq, SNU1079 in vitro, IFNg, Replicate 1 RNA-seq, SNU1079 in vit…
- GSM8224292 RNA-seq, SNU1079 in vitro, IFNg, Replicate 2 RNA-seq, SNU1079 in vit…
- GSM8224293 RNA-seq, SNU1079 in vitro, IFNg, Replicate 3 RNA-seq, SNU1079 in vit…
- GSM8224294 RNA-seq, SNU1079 in vitro, AG120, Replicate 1 RNA-seq, SNU1079 in vit…
- GSM8224295 RNA-seq, SNU1079 in vitro, AG120, Replicate 2 RNA-seq, SNU1079 in vit…
- GSM8224296 RNA-seq, SNU1079 in vitro, AG120, Replicate 3 RNA-seq, SNU1079 in vit…
- GSM8224297 RNA-seq, SNU1079 in vitro, AG120+IFNg, Replicate 1 RNA-seq, SNU1079 in vit…
- GSM8224298 RNA-seq, SNU1079 in vitro, AG120+IFNg, Replicate 2 RNA-seq, SNU1079 in vit…
- GSM8224299 RNA-seq, SNU1079 in vitro, AG120+IFNg, Replicate 3 RNA-seq, SNU1079 in vit…
- GSM8226604 RRBS, HuH28 in vitro
- GSM8226605 RRBS, SG231 in vitro
- GSM8226606 RRBS, SNU308 in vitro
- GSM8226607 RRBS, ICC3 in vitro
- GSM8226608 RRBS, RBE in vitro
- GSM8226609 RRBS, SNU1079 in vitro
- GSM8226610 RRBS, ICC5 in vitro
- GSM8226611 RRBS, YSCCC in vitro
- GSM8226612 RRBS, ICC10 in vitro
- GSM8226613 RRBS, ICC11 in vitro
- GSM8226614 RRBS, ICC21 in vitro
- GSM8226615 RRBS, ICC23 in vitro
- GSM8226616 RRBS, ICC25 in vitro
- GSM8226617 RRBS, MNNK1 in vitro
- GSM8226618 RRBS, KKU100 in vitro
- GSM8226619 RNA-seq, MGG152 in vitro, DMSO, Replicate 1 RNA-seq, MGG152 in vitr…
- GSM8226620 RNA-seq, MGG152 in vitro, DMSO, Replicate 2 RNA-seq, MGG152 in vitr…
- GSM8226621 RNA-seq, MGG152 in vitro, DMSO, Replicate 3 RNA-seq, MGG152 in vitr…
- GSM8226622 RNA-seq, MGG152 in vitro, IFNg, Replicate 1 RNA-seq, MGG152 in vitr…
- GSM8226623 RNA-seq, MGG152 in vitro, IFNg, Replicate 2 RNA-seq, MGG152 in vitr…
- GSM8226624 RNA-seq, MGG152 in vitro, IFNg, Replicate 3 RNA-seq, MGG152 in vitr…
- GSM8226625 RNA-seq, MGG152 in vitro, AG120, Replicate 1 RNA-seq, MGG152 in vitr…
- GSM8226626 RNA-seq, MGG152 in vitro, AG120, Replicate 2 RNA-seq, MGG152 in vitr…
- GSM8226627 RNA-seq, MGG152 in vitro, AG120, Replicate 3 RNA-seq, MGG152 in vitr…
- GSM8226628 RNA-seq, MGG152 in vitro, AG120+IFNg, Replicate 1 RNA-seq, MGG152 in vitr…
- GSM8226629 RNA-seq, MGG152 in vitro, AG120+IFNg, Replicate 2 RNA-seq, MGG152 in vitr…
- GSM8226630 RNA-seq, MGG152 in vitro, AG120+IFNg, Replicate 3 RNA-seq, MGG152 in vitr…
- GSM8226639 RNA-seq, PIC496-3 in vitro, DMSO, Replicate 1 RNA-seq, PIC496-3 in vi…
+ 163 more — browse all 203 samples with per-sample file links →
- GSE312944 Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity 140 samples shares inhibition, activate, immunity, induces
- GSE152277 G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT 30 samples shares idh1, mutant
- GSE250345 Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs 92 samples shares inhibition, activate
- GSE298396 PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors 16 samples shares inhibition, activate
- GSE71225 EZH2 inhibition as a targeted therapy for H3K27M mutant pediatric gliomas [ChIP-seq] 13 samples shares inhibition, mutant
- GSE264145 Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer 12 samples shares inhibition, immunity
- GSE291370 Selective inhibition of matrix mechanosensing in stromal cells attenuates cardiovascular fibrosis 9 samples shares inhibition, sensing
- GSE218717 EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition. 244 samples shares inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.