Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity
DNA methylation · human · 140 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 140 samples: 33 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE312944_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1377627 and SRA study SRP651373. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 30 samples read as cases, 38 as controls.
How we read this: 33 replicated groups read from 140 sample titles; they account for 140 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9347616 A549 cells, DMSO, 24 h, rep1 A549 cells, DMSO, 24 h,
- GSM9347617 A549 cells, DMSO, 24 h, rep2 A549 cells, DMSO, 24 h,
- GSM9347618 CAOV3 cells, DMSO, 24 h, rep1 CAOV3 cells, DMSO, 24 h,
- GSM9347619 CAOV3 cells, DMSO, 24 h, rep2 CAOV3 cells, DMSO, 24 h,
- GSM9347620 COV644 cells, DMSO, 24 h, rep1 COV644 cells, DMSO, 24 …
- GSM9347621 COV644 cells, DMSO, 24 h, rep2 COV644 cells, DMSO, 24 …
- GSM9347622 EFO21 cells, DMSO, 24 h, rep1 EFO21 cells, DMSO, 24 h,
- GSM9347623 EFO21 cells, DMSO, 24 h, rep2 EFO21 cells, DMSO, 24 h,
- GSM9347624 OE21 cells, DMSO, 24 h, rep1 OE21 cells, DMSO, 24 h,
- GSM9347625 OE21 cells, DMSO, 24 h, rep2 OE21 cells, DMSO, 24 h,
- GSM9347626 SKOV3 cells, DMSO, 24 h, rep1 SKOV3 cells, DMSO, 24 h,
- GSM9347627 SKOV3 cells, DMSO, 24 h, rep2 SKOV3 cells, DMSO, 24 h,
- GSM9347628 CAOV3 cells, STM3675, 24 h, rep1 CAOV3 cells, STM3675, 2…
- GSM9347629 CAOV3 cells, STM3675, 24 h, rep2 CAOV3 cells, STM3675, 2…
- GSM9357289 A549 cells, DMSO, 24 h, rep1 A549 cells, DMSO, 24 h,
- GSM9357290 A549 cells, DMSO, 24 h, rep2 A549 cells, DMSO, 24 h,
- GSM9357291 A549 cells, DMSO, 24 h, rep3 A549 cells, DMSO, 24 h,
- GSM9357292 A549 cells, STM3675, 24 h, rep1 A549 cells, STM3675, 24…
- GSM9357293 A549 cells, STM3675, 24 h, rep2 A549 cells, STM3675, 24…
- GSM9357294 A549 cells, STM3675, 24 h, rep3 A549 cells, STM3675, 24…
- GSM9357295 CAOV3 cells, DMSO, 24 h, rep1 CAOV3 cells, DMSO, 24 h,
- GSM9357296 CAOV3 cells, DMSO, 24 h, rep2 CAOV3 cells, DMSO, 24 h,
- GSM9357297 CAOV3 cells, DMSO, 24 h, rep3 CAOV3 cells, DMSO, 24 h,
- GSM9357298 CAOV3 cells, STM3675, 24 h, rep1 CAOV3 cells, STM3675, 2…
- GSM9357299 CAOV3 cells, STM3675, 24 h, rep2 CAOV3 cells, STM3675, 2…
- GSM9357300 CAOV3 cells, STM3675, 24 h, rep3 CAOV3 cells, STM3675, 2…
- GSM9357301 COV644 cells, DMSO, 24 h, rep1 COV644 cells, DMSO, 24 …
- GSM9357302 COV644 cells, DMSO, 24 h, rep2 COV644 cells, DMSO, 24 …
- GSM9357303 COV644 cells, DMSO, 24 h, rep3 COV644 cells, DMSO, 24 …
- GSM9357304 COV644 cells, STM3675, 24 h, rep1 COV644 cells, STM3675, …
- GSM9357305 COV644 cells, STM3675, 24 h, rep2 COV644 cells, STM3675, …
- GSM9357306 COV644 cells, STM3675, 24 h, rep3 COV644 cells, STM3675, …
- GSM9357307 EFO21 cells, DMSO, 24 h, rep1 EFO21 cells, DMSO, 24 h,
- GSM9357308 EFO21 cells, DMSO, 24 h, rep2 EFO21 cells, DMSO, 24 h,
- GSM9357309 EFO21 cells, DMSO, 24 h, rep3 EFO21 cells, DMSO, 24 h,
- GSM9357310 EFO21 cells, STM3675, 24 h, rep1 EFO21 cells, STM3675, 2…
- GSM9357311 EFO21 cells, STM3675, 24 h, rep2 EFO21 cells, STM3675, 2…
- GSM9357312 EFO21 cells, STM3675, 24 h, rep3 EFO21 cells, STM3675, 2…
- GSM9357313 OE21 cells, DMSO, 24 h, rep1 OE21 cells, DMSO, 24 h,
- GSM9357314 OE21 cells, DMSO, 24 h, rep2 OE21 cells, DMSO, 24 h,
+ 100 more — browse all 140 samples with per-sample file links →
- GSE264730 Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity 203 samples shares inhibition, immunity, induces
- GSE250345 Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs 92 samples shares inhibition, activates
- GSE298396 PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors 16 samples shares inhibition, activates
- GSE264145 Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer 12 samples shares inhibition, immunity
- GSE286384 METTL3-dependent m6A RNA Modifications Orchestrate the HNF1B-associated Redox and the Metabolic Vulnerability in Cancer [RNA-seq] 40 samples shares mettl3
- GSE218717 EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition. 244 samples shares inhibition
- GSE218716 EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition [ChIP-Seq/Cut&Run-Seq] 156 samples shares inhibition
- GSE266298 Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency 130 samples shares inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.