H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 57 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 57 samples: 15 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryosNature cell biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264193_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1101433 and SRA study SRP502294. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 30 samples.
How we read this: 15 replicated groups read from 57 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8213814 H3K27me2 FGO rep1 H3K27me2 FGO
- GSM8213815 H3K27me2 FGO rep2 H3K27me2 FGO
- GSM8213816 Input FGO
- GSM8213817 H3K27me2 4-cell rep1 H3K27me2 4-cell
- GSM8213818 H3K27me2 4-cell rep2 H3K27me2 4-cell
- GSM8213819 Input 4-cell
- GSM8213820 H3K27me2 8-cell rep1-1
- GSM8213821 H3K27me2 8-cell rep2
- GSM8213822 Input 8-cell
- GSM8213823 H3K27me2 morula rep1 H3K27me2 morula
- GSM8213824 H3K27me2 morula rep2 H3K27me2 morula
- GSM8213825 Input morula oocyte
- GSM8213826 H3K27me2 mESC 500 cells
- GSM8213827 H3K27me2 mESC 5k cells
- GSM8213828 Input mESC
- GSM8213829 H3K27me2 morula CTR rep1 H3K27me2 morula CTR
- GSM8213830 H3K27me2 morula CTR rep2 H3K27me2 morula CTR
- GSM8213831 H3K27me2 morula Jarid2 KO rep1 H3K27me2 morula Jarid2 …
- GSM8213832 H3K27me2 morula Jarid2 KO rep2 H3K27me2 morula Jarid2 …
- GSM8213833 Input morula CTR rep1
- GSM8213834 Input morula CTR rep2
- GSM8213835 Input morula Jarid2 KO rep1 Input morula Jarid2 KO
- GSM8213836 Input morula Jarid2 KO rep2 Input morula Jarid2 KO
- GSM8213837 H3K27me3 blastocyst WT rep1
- GSM8213838 H3K27me3 blastocyst CTR rep1 H3K27me3 blastocyst CTR
- GSM8213839 H3K27me3 blastocyst CTR rep2 H3K27me3 blastocyst CTR
- GSM8213840 H3K27me3 blastocyst Aebp2 KO rep1 H3K27me3 blastocyst Aeb…
- GSM8213841 H3K27me3 blastocyst Aebp2 KO rep2 H3K27me3 blastocyst Aeb…
- GSM8213842 H3K27me3 blastocyst Jarid2 KO rep1 H3K27me3 blastocyst Jar…
- GSM8213843 H3K27me3 blastocyst Jarid2 KO rep2 H3K27me3 blastocyst Jar…
- GSM8213844 H3K27me3 blastocyst Aebp2/Jarid2 dKO rep1 H3K27me3 blastocyst Aeb…
- GSM8213845 H3K27me3 blastocyst Aebp2/Jarid2 dKO rep2 H3K27me3 blastocyst Aeb…
- GSM8213846 Input blastocyst CTR
- GSM8213847 Input blastocyst Aebp2 KO
- GSM8213848 Input blastocyst Jarid2 KO
- GSM8213849 Input blastocyst Aebp2/Jarid2 dKO
- GSM8213850 H3K36me3 4-cell rep1
- GSM8213851 CUT&RUN JARID2 morula rep1 CUT&RUN JARID2 morula
- GSM8213852 CUT&RUN JARID2 morula rep2 CUT&RUN JARID2 morula
- GSM8213853 CUT&RUN SUZ12 morula Jarid2 CTR rep1 CUT&RUN SUZ12 morula Ja…
+ 17 more — browse all 57 samples with per-sample file links →
- GSE287032 H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation [ChIP-seq] 20 samples shares h3k27, heterochromatin, chip-seq
- GSE206180 Stepwise de novo establishment of inactive X chromosome architecture in early development [XEN cells ChIP-seq] 20 samples shares establishment, stepwise, chip-seq
- GSE212153 Requirements for Establishment and Epigenetic Stability of Mammalian Heterochromatin [ChIP-Seq] 18 samples shares heterochromatin, establishment, chip-seq
- GSE262390 Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA by enhancing H3K36me3 at gene bodies and excluding H3K27me3 from promoters [ChIP-seq] 79 samples shares h3k27, chip-seq
- GSE278811 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization [ChIP-Seq] 77 samples shares h3k27, chip-seq
- GSE255762 ChIP-seq for PPARg, RXRa, and H3K27Ac in inflammation-associated unsaturated fatty acid-supplemented Th2 cells 25 samples shares h3k27, chip-seq
- GSE261412 Acute hormonal signaling-induced 3D chromatin loop reorganization controls adipocyte thermogenesis [ChIP-Seq mouse, H3K27ac, H3K4me3, H2AZ] 24 samples shares h3k27, chip-seq
- GSE277547 A novel histone H3K27 reader, CBFA2T2, inhibits H3K27me3 demethylation and tumor growth by regulating metabolic genes and metabolite levels [ChIP-seq II] 19 samples shares h3k27, chip-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.