A novel histone H3K27 reader, CBFA2T2, inhibits H3K27me3 demethylation and tumor growth by regulating metabolic genes and metabolite levels [ChIP-seq II]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 19 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 19 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CBFA2T2: a novel H3K27 reader regulating metabolism and tumor growthMolecular cancer · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277547_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1162782 and SRA study SRP533577. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 19 sample titles: 19 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8524330 H33WT-CBFA2T2KO-input
- GSM8524331 H33WT-CBFA2T2KO-CBFA2T2-Chip
- GSM8524332 H33WT-inputforCBFA2T2
- GSM8524333 H33WT-CBFA2T2-ChIP
- GSM8524334 H33K27M-inputforCBFA2T2
- GSM8524335 H33K27M-CBFA2T2-ChIP
- GSM8524336 H33WT-HA-ChIP
- GSM8524337 H33WT-inputforHAandK4me3
- GSM8524338 H33WT-H3K4me3-ChIP
- GSM8524339 H33WT-CBFA2T2KO-HA-ChIP
- GSM8524340 H33WT-CBFA2T2KO-inputforHAandK4me3
- GSM8524341 H33WT-CBFA2T2KO-H3K4me3-ChIP
- GSM8524342 H33K27M-HA-ChIP
- GSM8524343 H33WT-inputforH3K27me3
- GSM8524344 H33WT-CBFA2T2KO-inputforH3K27me3
- GSM8524345 H33WT-CBFA2T2KO-H3K27me3-ChIP
- GSM8524346 H33WT-H3K27me3-ChIP
- GSM8524347 H33K27M-inputforH3K27me3
- GSM8524348 H33K27M-H3K27me3-ChIP
- GSE262390 Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA by enhancing H3K36me3 at gene bodies and excluding H3K27me3 from promoters [ChIP-seq] 79 samples shares h3k27me3, h3k27, chip-seq
- GSE278811 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization [ChIP-Seq] 77 samples shares h3k27me3, h3k27, chip-seq
- GSE275142 The Fosl1-Kdm6b Axis Controls Skeletal Muscle Fibrosis by Regulating Histone H3K27me3 [Cut&Tag] 24 samples shares h3k27me3, h3k27, regulating
- GSE287032 H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation [ChIP-seq] 20 samples shares h3k27me3, h3k27, chip-seq
- GSE281043 The genome wide mapping of H3K4kme3, H3K27ac and H3K27me3 in Ctcf f/f and Ctcf Δ/Δ CALM-AF10 AML cells [ChiP-seq] 16 samples shares h3k27me3, h3k27, chip-seq
- GSE330241 Long-term maintenance of H3K27me3 in postmitotic neurons is dispensable for gene expression regulation [ChIP-Seq] 16 samples shares h3k27me3, h3k27, chip-seq
- GSE281946 Abnormal H3K27me3 underlies degenerative spermatogonial stem cells in cryptorchid testis [ChIP-Seq] 11 samples shares h3k27me3, h3k27, chip-seq
- GSE242461 TET Proteins Control Early-Stage Stem Cell Differentiation via H3K27me3, Not DNA Demethylation 30 samples shares h3k27me3, h3k27, demethylation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.