MASH fibrosis mouse model for circadian analyses of HSC
RNA-seq (gene expression) · mouse · 22 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting the liver clock improves fibrosis by restoring TGF-β signalingJournal of hepatology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264250_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1101541 and SRA study SRP502427. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 6 replicated groups read from 22 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8214966 Control_1_ZT6 Control_1_ZT
- GSM8214967 Control_1_ZT12 Control_1_ZT
- GSM8214968 Control_1_ZT18 Control_1_ZT
- GSM8214969 Control_1_ZT0 Control_1_ZT
- GSM8214970 Control_2_ZT6 Control_2_ZT
- GSM8214971 Control_2_ZT12 Control_2_ZT
- GSM8214972 Control_2_ZT18 Control_2_ZT
- GSM8214973 Control_2_ZT0 Control_2_ZT
- GSM8214974 Control_3_ZT18 Control_3_ZT
- GSM8214975 Control_3_ZT0 Control_3_ZT
- GSM8214976 Diet_1_ZT6 Diet_1_ZT
- GSM8214977 Diet_1_ZT12 Diet_1_ZT
- GSM8214978 Diet_1_ZT18 Diet_1_ZT
- GSM8214979 Diet_1_ZT0 Diet_1_ZT
- GSM8214980 Diet_2_ZT6 Diet_2_ZT
- GSM8214981 Diet_2_ZT12 Diet_2_ZT
- GSM8214982 Diet_2_ZT18 Diet_2_ZT
- GSM8214983 Diet_2_ZT0 Diet_2_ZT
- GSM8214984 Diet_3_ZT6 Diet_3_ZT
- GSM8214985 Diet_3_ZT12 Diet_3_ZT
- GSM8214986 Diet_3_ZT18 Diet_3_ZT
- GSM8214987 Diet_3_ZT0 Diet_3_ZT
- GSE316023 AI digital pathology as a key tool providing in-depth understanding of the progression and regression of MASH and fibrosis in male mouse models 77 samples shares mash, fibrosis
- GSE279351 Liver-specific inactivation of Cideb improves metabolic profiles and ameliorates steatohepatitis and fibrosis in animal models for MASH 45 samples shares mash, fibrosis
- GSE304692 Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH) [RNAseq_palmitate_silencing] 24 samples shares mash, circadian
- GSE301751 Therapeutic Efficacy, Biomarker Signatures and Translatability of Semaglutide in the Liver Biopsy-Confirmed GAN DIO-MASH Mouse Model (study 7/9) 53 samples shares mash
- GSE310507 Therapeutic Efficacy, Biomarker Signatures and Translatability of Semaglutide in the Liver Biopsy-Confirmed GAN DIO-MASH Mouse Model (study 6) 24 samples shares mash
- GSE265909 yHSC and oHSC scRNAseq with oHSC AThi ATlo Index Sorting. Assessing the transcriptional changes associated with autophagy engagement in old hematopoietic stem cells at single cell resolution. [scRNA-Seq] 563 samples shares hsc
- GSE309251 Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction 347 samples shares mash
- GSE304977 Core clock pharmacological control in the mouse hepatic stellate cell (HSC) EMS404 24 samples shares hsc
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.