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Effect of umbilical cord mesenchymal stem cells on preadipocyte differentiation

GSE264277 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/23 Platform GPL24247
Summary
Umbilical cord mesenchymal stem cells (ucMSCs), being multipotent stem cells located within Wharton's jelly, have garnered substantial interest in the medical field due to their low immunogenicity and proven capabilities in inflammation attenuation, immune modulation, and regenerative applications. Multiple studies have evidenced that ucMSCs not only contribute to disease treatment but also exert an effect on adipose tissue, hinting at a potential relationship between these entities. It is widely acknowledged that adipose tissue predominantly originates from mesenchymal stem cells (MSCs), and that MSCs within a lipogenic milieu show increased commitment towards the adipogenic lineage. Consequently, we speculate that a complex interplay might exist between hucMSCs and adipose tissue during adipocyte differentiation. This study aims to investigate the specific nature of this influence and elucidate the underlying mechanisms involved.
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Direct links to NCBI, no account and no request form: the whole study as GSE264277_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1101840 and SRA study SRP502573. Searching any of these in the dataset finder brings you back here.

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