Chemotherapy promotes antigen presentation in monocytes of patients with high-grade serous ovarian carcinoma [scRNAseq]
Single-cell RNA-seq · human · 12 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinomaFrontiers in immunology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264489_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1102697 and SRA study SRP503019. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 6 samples read as cases, 6 as controls.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8218878 scRNA-seq_Ov1 PBMC of HGSOC patients
- GSM8218879 scRNA-seq_Ov2 PBMC of HGSOC patients
- GSM8218880 scRNA-seq_Ov3 PBMC of HGSOC patients
- GSM8218881 scRNA-seq_Ov4 PBMC of HGSOC patients
- GSM8218882 scRNA-seq_Ov5 PBMC of HGSOC patients
- GSM8218883 scRNA-seq_Ov6 PBMC of HGSOC patients
- GSM8218884 scRNA-seq_Dn1 PBMC of healthy donors
- GSM8218885 scRNA-seq_Dn2 PBMC of healthy donors
- GSM8218886 scRNA-seq_Dn3 PBMC of healthy donors
- GSM8218887 scRNA-seq_Dn4 PBMC of healthy donors
- GSM8218888 scRNA-seq_Dn5 PBMC of healthy donors
- GSM8218889 scRNA-seq_Dn6 PBMC of healthy donors
- GSE224392 Immunotherapies that repolarize macrophages and regulatory T cells enhance the effect of chemotherapy in high-grade serous ovarian cancer (Human) 21 samples shares chemotherapy, high-grade, ovarian
- GSE282004 Tumor Exosome-transmitted LncRNA CATED Promotes Platinum-resistant in High-grade Serous Ovarian Cancer 17 samples shares high-grade, promotes, ovarian
- GSE268514 Integrative genomic analysis of Korean high-grade serous ovarian cancer 161 samples shares high-grade, ovarian
- GSE313768 Temporal regulation of human reactive astrocytes reveals their capacity for antigen presentation 115 samples shares presentation, antigen
- GSE271757 Pembrolizumab plus chemotherapy in frontline treatment of advanced epithelial ovarian cancer: clinical and translational results from a phase II trial 97 samples shares chemotherapy, ovarian
- GSE222556 Neoadjuvant PARPi or Chemotherapy in Ovarian Cancer Informs Targeting Effector Treg Cells for Homologous-Recombination-Deficient Tumors [10x scRNA-seq] 67 samples shares chemotherapy, ovarian
- GSE286888 Comparative gene expression profiling of high-grade serous ovarian cancer cells exposed to cisplatin or CX-5461 60 samples shares high-grade, ovarian
- GSE266577 Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer 48 samples shares chemotherapy, ovarian
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.