PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer [Western Diet + CCl4]
RNA-seq (gene expression) · mouse · 19 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 19 × Western Diet + CCl4Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancerCell metabolism · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264521_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1102894 and SRA study SRP503169. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 19 samples.
How we read this: 1 replicated groups read from 19 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8219447 Western Diet + CCl4 1 Western Diet + CCl4
- GSM8219448 Western Diet + CCl4 2 Western Diet + CCl4
- GSM8219449 Western Diet + CCl4 3 Western Diet + CCl4
- GSM8219450 Western Diet + CCl4 4 Western Diet + CCl4
- GSM8219451 Western Diet + CCl4 6 Western Diet + CCl4
- GSM8219452 Western Diet + CCl4 7 Western Diet + CCl4
- GSM8219453 Western Diet + CCl4 8 Western Diet + CCl4
- GSM8219454 Western Diet + CCl4 9 Western Diet + CCl4
- GSM8219455 Western Diet + CCl4 10 Western Diet + CCl4
- GSM8219456 Western Diet + CCl4 11 Western Diet + CCl4
- GSM8219457 Western Diet + CCl4 12 Western Diet + CCl4
- GSM8219458 Western Diet + CCl4 13 Western Diet + CCl4
- GSM8219459 Western Diet + CCl4 14 Western Diet + CCl4
- GSM8219460 Western Diet + CCl4 15 Western Diet + CCl4
- GSM8219461 Western Diet + CCl4 16 Western Diet + CCl4
- GSM8219462 Western Diet + CCl4 17 Western Diet + CCl4
- GSM8219463 Western Diet + CCl4 18 Western Diet + CCl4
- GSM8219464 Western Diet + CCl4 19 Western Diet + CCl4
- GSM8219465 Western Diet + CCl4 20 Western Diet + CCl4
- GSE264520 PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer [Normal Chow diet] 14 samples shares pkd1, steatohepatitis, cirrhotic, promoting, inhibit, without
- GSE239861 Bardoxolone methyl improves nonalcoholic steatohepatitis through inhibition of macrophage recruitment 12 samples shares steatohepatitis, inhibit
- GSE236832 Inhibition of adipose triglyceride lipase alleviates non-alcoholic steatohepatitis in diabetic mice via impaired PPARa signalling favouring hydrophilic bile acid composition 9 samples shares steatohepatitis, inhibit
- GSE98782 Therapeutic Inhibition of Inflammatory Monocyte Recruitment Reduces Steatohepatitis and Liver Fibrosis 8 samples shares steatohepatitis, inhibit
- GSE249350 Tranilast inhibits hepatic lipid response in nonalcoholic steatohepatitis by deacetylating LKB1 8 samples shares steatohepatitis, inhibit
- GSE325089 Limonoid DDK restores mitochondrial redox homeostasis to alleviate metabolic dysfunction-associated steatohepatitis via promoting SDHA deacetylation and SDH complex activity 6 samples shares steatohepatitis, promoting
- GSE308258 A novel pharmacological inhibitor of MAP4K4 activity protect against preclinical model of metabolic dysfunction-associated steatohepatitis 3 samples shares steatohepatitis, inhibit
- GSE268336 Transcriptome Analysis Reveals Potential Protective Effects and Biomarkers of Pien Tze Huang on CCl4-induced Liver Cancer (lncRNA and mRNA) 18 samples shares ccl4
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.