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single-cell RNA-seq of cardiac tissue from offsprings of dams with different fibre intake levels

GSE264691 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/04/24 Platform GPL21103
Summary
We proposed that the maternal intake of fibre could influence the epigenetic conditions in the womb, consequently altering the cardiac characteristics of the offspring. Additionally, we speculated that maternal fibre intake might lead to significant changes in cardiac gene expression in the offspring by promoting the production of short-chain fatty acids (SCFAs). To examine the impact of maternal high fibre intake on the cellular composition of the heart, we conducted single-cell RNA sequencing (scRNA-seq) analysis on cardiac tissue from 6-week-old offspring who had not been subjected to any external challenges.
Published in
Maternal Diet and Gut Microbiota Influence Predisposition to Cardiovascular Disease in Offspring
Jama HA, Dona MSI, Dinakis E et al. · Circulation research 2024 · PMID 39016011 · doi:10.1161/CIRCRESAHA.124.324614
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Also filed as BioProject PRJNA1103151 and SRA study SRP503301. Searching any of these in the dataset finder brings you back here.

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