GEO series
Gata2 promotes drug resistance in Acute Myeloid Leukemia (AML) [ChIP-Seq]
GSE264719
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2025/04/30
GPL24247
Summary
In this study, we generated mouse models of MLL-AF9-driven AML (MA9) harboring conditional alleles for Gata2 gene to precisely investigate the role of Gata2 in drug resistance and progression of MLL-rearranged (MLL-r) AML. Our findings revealed a novel mechanism for Gata2 in blunting p53 mediated apoptosis via transcriptional repression of Rassf4, a regulator of Mdm2 protein stability.
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