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RNA-seq analysis of intestinal epithelia of Ruminococcus torques treated mice

GSE265852 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/04 Platform GPL24247
Summary
Purpose: To explore the influence of Ruminococcus torques treatment in mice intestinal epithelia. Method: Mice were pretreated with antibiotics for 3 days, then mice were fed with a high-fat diet and gavaged with PBS or R. torques (108 CFU/mouse) every 3 days for 2 weeks. mRNA profiles were generated by deep sequencing.Results: Several signaling pathways were changed after R. torques treatment, including response to hypoxia pathway. R. torques treatment significantly inhibits Epas1-mediated transcription effect.
Published in
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH
Zhang Y, Wang X, Lin J et al. · Cell metabolism 2024 · PMID 39079531 · doi:10.1016/j.cmet.2024.07.004
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Also filed as BioProject PRJNA1104543 and SRA study SRP504086. Searching any of these in the dataset finder brings you back here.

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