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Analysis of Gene Expression in the Recovered Mouse Brain following Zika Virus Infection

GSE265861 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/05/20 Platform GPL24247
Summary
Zika virus (ZIKV) is a member of the Flaviviridae family, transmitted by Aedes mosquitoes. ZIKV can be transmitted from pregnant woman to fetus and causes microcephaly and neuronal defects. Patients infected with ZIKV showed increased levels of proinflammatory cytokines compared to healthy individuals and neurological changes even after recovery. However, the detailed mechanism of how neuronal defects occurs after recovery from ZIKV infection has never been investigated in vivo. Here, we found that viral RNA loads were highest in mouse brain tissue 7 days after ZIKV infection and were equivalent to uninfected controls after 21 days, suggesting that mice recovered after 21 days of ZIKV infection. To explore the pathological mechanisms of neuronal defects after recovery from ZIKV infection, we performed RNA-sequencing in mouse cerebral cortex obtained 7 days and 21 days after ZIKV infection.
Published in
Sustained Microglial Activation Promotes Synaptic Loss and Neuronal Dysfunction after Recovery from ZIKV Infection
Kim N, Choi H, Kim U et al. · International journal of molecular sciences 2024 · PMID 39273400 · doi:10.3390/ijms25179451
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Direct links to NCBI, no account and no request form: the whole study as GSE265861_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1104568 and SRA study SRP504099. Searching any of these in the dataset finder brings you back here.

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