← BioTransfer GEO Dataset Finder
GEO series

Effect of Large Brown Adipocyte-secreted Proteins on Type 1 Diabetic Mice (NOD) Brown Adipose Tissue

GSE265915 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/03/24 Platform GPL24247
Summary
Brown adipose tissue has been recognized as an important endocrine organ for metabolic health. In our study, we found that large proteins secreted by brown adipocyte (CB-100) promote the recovery of euglycemia in type 1 diabetic mice (NOD) when injected at an early stage of the disease. To further elucidate the in vivo effects of CB-100, we analyzed brown adipose tissue from both CB-100 and sham-treated mice. Differential gene expression analysis revealed that BAT from CB-100-treated NOD mice exhibited higher thermogenic activity. This suggests that the recovery of euglycemia in CB-100-treated mice may be attributed to enhanced thermogenic activity of the brown adipose tissue, which also contributes to glucose clearance
Published in
Regulation of Type 1 Diabetes via Brown Adipocyte-Secreted Proteins and the Novel Glucagon Regulator Nidogen-2
Lee J, Ustione A, Wilkerson EM et al. · Diabetes 2025 · PMID 40029688 · doi:10.2337/db24-1003
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE265915_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1104676 and SRA study SRP504077. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 7 more — browse all 7 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.